Cryogen-free dissolution dynamic nuclear polarization polarizer operating at 3.35 T, 6.70 T, and 10.1 T

Jan Henrik Ardenkjær-Larsen*, Sean Bowen, Jan Raagaard Petersen, Oleksandr Rybalko, Mads Sloth Vinding, Marcus Ullisch, Niels Chr Nielsen

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

A novel dissolution dynamic nuclear polarization (dDNP) polarizer platform is presented. The polarizer meets a number of key requirements for in vitro, preclinical, and clinical applications. It uses no liquid cryogens, operates in continuous mode, accommodates a wide range of sample sizes up to and including those required for human studies, and is fully automated. It offers a wide operational window both in terms of magnetic field, up to 10.1 T, and temperature, from room temperature down to 1.3 K. The polarizer delivers a 13C liquid state polarization for [1-13 C]pyruvate of 70%. The build-up time constant in the solid state is approximately 1200 s (20 minutes), allowing a sample throughput of at least one sample per hour including sample loading and dissolution. We confirm the previously reported strong field dependence in the range 3.35 to 6.7 T, but see no further increase in polarization when increasing the magnetic field strength to 10.1 T for [1-13 C]pyruvate and trityl. Using a custom dry magnet, cold head and recondensing, closed-cycle cooling system, combined with a modular DNP probe, and automation and fluid handling systems, we have designed a unique dDNP system with unrivalled flexibility and performance.
Original languageEnglish
JournalMagnetic Resonance in Medicine
Volume81
Issue number3
Pages (from-to)2184-2194
Number of pages11
ISSN0740-3194
DOIs
Publication statusPublished - 2019

Keywords

  • Dissolution dynamic nuclear polarization
  • Dry magnet
  • Hyperpolarization
  • Polarizer

Cite this

Ardenkjær-Larsen, Jan Henrik ; Bowen, Sean ; Petersen, Jan Raagaard ; Rybalko, Oleksandr ; Vinding, Mads Sloth ; Ullisch, Marcus ; Nielsen, Niels Chr. / Cryogen-free dissolution dynamic nuclear polarization polarizer operating at 3.35 T, 6.70 T, and 10.1 T. In: Magnetic Resonance in Medicine. 2019 ; Vol. 81, No. 3. pp. 2184-2194.
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title = "Cryogen-free dissolution dynamic nuclear polarization polarizer operating at 3.35 T, 6.70 T, and 10.1 T",
abstract = "A novel dissolution dynamic nuclear polarization (dDNP) polarizer platform is presented. The polarizer meets a number of key requirements for in vitro, preclinical, and clinical applications. It uses no liquid cryogens, operates in continuous mode, accommodates a wide range of sample sizes up to and including those required for human studies, and is fully automated. It offers a wide operational window both in terms of magnetic field, up to 10.1 T, and temperature, from room temperature down to 1.3 K. The polarizer delivers a 13C liquid state polarization for [1-13 C]pyruvate of 70{\%}. The build-up time constant in the solid state is approximately 1200 s (20 minutes), allowing a sample throughput of at least one sample per hour including sample loading and dissolution. We confirm the previously reported strong field dependence in the range 3.35 to 6.7 T, but see no further increase in polarization when increasing the magnetic field strength to 10.1 T for [1-13 C]pyruvate and trityl. Using a custom dry magnet, cold head and recondensing, closed-cycle cooling system, combined with a modular DNP probe, and automation and fluid handling systems, we have designed a unique dDNP system with unrivalled flexibility and performance.",
keywords = "Dissolution dynamic nuclear polarization, Dry magnet, Hyperpolarization, Polarizer",
author = "Ardenkj{\ae}r-Larsen, {Jan Henrik} and Sean Bowen and Petersen, {Jan Raagaard} and Oleksandr Rybalko and Vinding, {Mads Sloth} and Marcus Ullisch and Nielsen, {Niels Chr}",
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Cryogen-free dissolution dynamic nuclear polarization polarizer operating at 3.35 T, 6.70 T, and 10.1 T. / Ardenkjær-Larsen, Jan Henrik; Bowen, Sean; Petersen, Jan Raagaard; Rybalko, Oleksandr; Vinding, Mads Sloth; Ullisch, Marcus; Nielsen, Niels Chr.

In: Magnetic Resonance in Medicine, Vol. 81, No. 3, 2019, p. 2184-2194.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Cryogen-free dissolution dynamic nuclear polarization polarizer operating at 3.35 T, 6.70 T, and 10.1 T

AU - Ardenkjær-Larsen, Jan Henrik

AU - Bowen, Sean

AU - Petersen, Jan Raagaard

AU - Rybalko, Oleksandr

AU - Vinding, Mads Sloth

AU - Ullisch, Marcus

AU - Nielsen, Niels Chr

PY - 2019

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N2 - A novel dissolution dynamic nuclear polarization (dDNP) polarizer platform is presented. The polarizer meets a number of key requirements for in vitro, preclinical, and clinical applications. It uses no liquid cryogens, operates in continuous mode, accommodates a wide range of sample sizes up to and including those required for human studies, and is fully automated. It offers a wide operational window both in terms of magnetic field, up to 10.1 T, and temperature, from room temperature down to 1.3 K. The polarizer delivers a 13C liquid state polarization for [1-13 C]pyruvate of 70%. The build-up time constant in the solid state is approximately 1200 s (20 minutes), allowing a sample throughput of at least one sample per hour including sample loading and dissolution. We confirm the previously reported strong field dependence in the range 3.35 to 6.7 T, but see no further increase in polarization when increasing the magnetic field strength to 10.1 T for [1-13 C]pyruvate and trityl. Using a custom dry magnet, cold head and recondensing, closed-cycle cooling system, combined with a modular DNP probe, and automation and fluid handling systems, we have designed a unique dDNP system with unrivalled flexibility and performance.

AB - A novel dissolution dynamic nuclear polarization (dDNP) polarizer platform is presented. The polarizer meets a number of key requirements for in vitro, preclinical, and clinical applications. It uses no liquid cryogens, operates in continuous mode, accommodates a wide range of sample sizes up to and including those required for human studies, and is fully automated. It offers a wide operational window both in terms of magnetic field, up to 10.1 T, and temperature, from room temperature down to 1.3 K. The polarizer delivers a 13C liquid state polarization for [1-13 C]pyruvate of 70%. The build-up time constant in the solid state is approximately 1200 s (20 minutes), allowing a sample throughput of at least one sample per hour including sample loading and dissolution. We confirm the previously reported strong field dependence in the range 3.35 to 6.7 T, but see no further increase in polarization when increasing the magnetic field strength to 10.1 T for [1-13 C]pyruvate and trityl. Using a custom dry magnet, cold head and recondensing, closed-cycle cooling system, combined with a modular DNP probe, and automation and fluid handling systems, we have designed a unique dDNP system with unrivalled flexibility and performance.

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KW - Polarizer

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