CROSS-REACTION PATTERNS IN GUINEA-PIGS SENSITIZED TO ACRYLIC-MONOMERS

S. Clemmensen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The cross-reaction patterns of selected acrylate and methacrylate esters were investigated using the guinea pig maximization test. Methacrylates were less potent sensitizers than acrylates. Cross-sensitization was found between (meth)acrylates with closely related core structures, most extensively between hydroxyethyl and hydroxypropyl congeners. The importance of considering not only the functional group but also the core structure when assessing potential interactions was emphasized as butanedioldiglycidylether, hexamethylenediisocyanate and hexanedioldiacrylate - all with linear 6-atom cores and different functional groups - cross-reacted.
Original languageEnglish
JournalDrug and Chemical Toxicology
Volume7
Issue number6
Pages (from-to)527-540
ISSN0148-0545
DOIs
Publication statusPublished - 1984

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