Abstract
The present invention relates to an engineered Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) system comprising engineered dual guide nucleic acids (e.g., RNAs) capable of activating a CRISPR- Associated (Cas) nuclease, such as a type V-A Cas nuclease. Also provided are methods of targeting, editing, and/or modifying a nucleic acid using the engineered CRISPR system, and compositions and cells comprising the engineered CRISPR system.
| Original language | English |
|---|---|
| IPC | A61K 31/ 713 A I |
| Patent number | WO2021067788 |
| Filing date | 02/10/2020 |
| Country/Territory | International Bureau of the World Intellectual Property Organization (WIPO) |
| Priority date | 03/10/2019 |
| Priority number | US201962910055P |
| Publication status | Published - 8 Apr 2021 |