Crispr systems with engineered dual guide nucleic acids

Ryan Gill (Inventor), Tanya Warnecke (Inventor), Andrea Barghetti (Inventor), Line Poulsen (Inventor)

Research output: Patent

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Abstract

The present invention relates to an engineered Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) system comprising engineered dual guide nucleic acids (e.g., RNAs) capable of activating a CRISPR- Associated (Cas) nuclease, such as a type V-A Cas nuclease. Also provided are methods of targeting, editing, and/or modifying a nucleic acid using the engineered CRISPR system, and compositions and cells comprising the engineered CRISPR system.

Original languageEnglish
IPCA61K 31/ 713 A I
Patent numberWO2021067788
Filing date02/10/2020
Country/TerritoryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date03/10/2019
Priority numberUS201962910055P
Publication statusPublished - 8 Apr 2021

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