Crispr systems with engineered dual guide nucleic acids

Ryan Gill; Tanya Warnecke; Andrea Barghetti; Line Poulsen

Crispr systems with engineered dual guide nucleic acids

Ryan Gill (Inventor), Tanya Warnecke (Inventor), Andrea Barghetti (Inventor), Line Poulsen (Inventor)

Novo Nordisk Foundation Center for Biosustainability

Research output: Patent

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Abstract

The present invention relates to an engineered Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) system comprising engineered dual guide nucleic acids (e.g., RNAs) capable of activating a CRISPR- Associated (Cas) nuclease, such as a type V-A Cas nuclease. Also provided are methods of targeting, editing, and/or modifying a nucleic acid using the engineered CRISPR system, and compositions and cells comprising the engineered CRISPR system.

Original language	English
IPC	A61K 31/ 713 A I
Patent number	WO2021067788
Filing date	02/10/2020
Country/Territory	International Bureau of the World Intellectual Property Organization (WIPO)
Priority date	03/10/2019
Priority number	US201962910055P
Publication status	Published - 8 Apr 2021

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abstract = "The present invention relates to an engineered Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) system comprising engineered dual guide nucleic acids (e.g., RNAs) capable of activating a CRISPR- Associated (Cas) nuclease, such as a type V-A Cas nuclease. Also provided are methods of targeting, editing, and/or modifying a nucleic acid using the engineered CRISPR system, and compositions and cells comprising the engineered CRISPR system.",

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T1 - Crispr systems with engineered dual guide nucleic acids

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AU - Warnecke, Tanya

AU - Barghetti, Andrea

AU - Poulsen, Line

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N2 - The present invention relates to an engineered Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) system comprising engineered dual guide nucleic acids (e.g., RNAs) capable of activating a CRISPR- Associated (Cas) nuclease, such as a type V-A Cas nuclease. Also provided are methods of targeting, editing, and/or modifying a nucleic acid using the engineered CRISPR system, and compositions and cells comprising the engineered CRISPR system.

AB - The present invention relates to an engineered Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) system comprising engineered dual guide nucleic acids (e.g., RNAs) capable of activating a CRISPR- Associated (Cas) nuclease, such as a type V-A Cas nuclease. Also provided are methods of targeting, editing, and/or modifying a nucleic acid using the engineered CRISPR system, and compositions and cells comprising the engineered CRISPR system.

M3 - Patent

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Crispr systems with engineered dual guide nucleic acids

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