Coxiella burnetii associated placental lesions and infection level in parturient cows

Mette Sif Hansen, Annie Rodolakis, Denis Cochonneau, Jens F. Agger, Anna-Bodil Christoffersen, Tim Kåre Jensen, Jørgen S. Agerholm

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Cotyledons (n=170) from dairy cattle were analysed for Coxiella burnetii by real-time (rt) PCR targeting the IS1111a and icd genes. Positive cases (n=90) and a random selection of negative cases (n=20) were examined by histology, immunohistochemistry and, if infection level was high, by fluorescence in situ hybridisation. PCR results were compared to bulk tank milk (BTM) antibody levels.Placental infection was detected in cows from herds at all BTM antibody levels. However the likelihood of placental infection was generally higher in herds with intermediate or high BMT antibody levels than in herds with low antibody levels. Histological examination revealed a range of mostly mild cotyledonary changes; C. burnetii infection was only rarely associated with inflammation. This may explain why bovine Q fever is usually not clinically apparent. Nevertheless, infected cattle will shed C. burnetii at calving and this can occur even in herds without BTM antibodies.
    Original languageEnglish
    JournalVeterinary Journal
    Volume190
    Issue number2
    Pages (from-to)e135-e139
    ISSN1090-0233
    DOIs
    Publication statusPublished - 2011

    Keywords

    • Coxiella burnetii
    • Cattle
    • Shedding
    • Placenta
    • Reproduction
    • Infection

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