TY - ADVS
T1 - Cover Feature: Biochemical Characterization of β‐Amino Acid Incorporation in Fluvirucin B2 Biosynthesis (ChemBioChem 13/2018)
A2 - Barajas, Jesus F.
A2 - Zargar, Amin
A2 - Pang, Bo
A2 - Benites, Veronica T.
A2 - Gin, Jennifer
A2 - Baidoo, Edward E. K.
A2 - Petzold, Christopher J.
A2 - Hillson, Nathan J.
A2 - Keasling, Jay D.
PY - 2018
Y1 - 2018
N2 - The cover feature picture shows fluvirucin B2 and the origin of the nitrogen atom within its macrolactam core: l‐aspartate. The selection or “loading” of l‐aspartate as the starting building block in fluvirucin B2 production is mediated by a set of core enzymes that process and prime the polyketide synthase. We demonstrate the promiscuity of the loading pathway: its ability to use a range of amino acids and further illustrate its ability to load different β‐amino acids selectively onto a PKS loading platform. More information can be found in the communication by J. D. Keasling et al. on page 1391 in Issue 13, 2018 (DOI: 10.1002/cbic.201800169).
AB - The cover feature picture shows fluvirucin B2 and the origin of the nitrogen atom within its macrolactam core: l‐aspartate. The selection or “loading” of l‐aspartate as the starting building block in fluvirucin B2 production is mediated by a set of core enzymes that process and prime the polyketide synthase. We demonstrate the promiscuity of the loading pathway: its ability to use a range of amino acids and further illustrate its ability to load different β‐amino acids selectively onto a PKS loading platform. More information can be found in the communication by J. D. Keasling et al. on page 1391 in Issue 13, 2018 (DOI: 10.1002/cbic.201800169).
U2 - 10.1002/cbic.201800299
DO - 10.1002/cbic.201800299
M3 - 2D/3D (physical products)
PB - Wiley
ER -