Corymbiferan lactones from Penicillium hordei: Stimulation of novel phenolic metabolites using plant tissue media

David Patrick Overy, J.W. Blunt

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Cultivation of a strain of Penicillium hordei on macerated tulip tissue agar resulted in the stimulated production of a series of four novel hydroxymethyl naphthalene carboxylic acid lactones from the fungus. The naphthalene derivatives were isolated using a combination of vacuum liquid chromatography and preparative HPLC. Their structures were determined by 1D and 2D NMR techniques in conjunction with high-resolution electrospray mass spectrometry (HRESIMS). These metabolites were given the trivial names corymbiferan lactones A-D (1-4).
    Original languageEnglish
    JournalJournal of Natural Products
    Volume67
    Pages (from-to)1850-1853
    ISSN0163-3864
    Publication statusPublished - 2004

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