Cortical N-acetyl aspartate is a predictor of long-term clinical disability in multiple sclerosis

Xingchen Wu, Lars G. Hanson, Arnold Jesper Møller Skimminge, Per Soelberg Sorensen, Olaf Bjarne Paulson, Henrik Kahr Mathiesen, Morten Blinkenberg

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Objective: To evaluate the prognostic value of the cortical N-acetyl aspartate to creatine ratio (NAA/Cr) in early relapsing-remitting multiple sclerosis (RRMS). Methods: Sixteen patients with newly diagnosed RRMS were studied by serial MRI and MR spectroscopic imaging (MRSI) once every 6 months for 24 months. Clinical examinations, including the expanded disability status scale (EDSS), were performed at baseline, month 24, and at year 7. Results: Baseline cortical NAA/Cr correlated inversely with EDSS at month 24 (r = -0.61, P <0.05), and patients with EDSS >= 4 had a lower baseline cortical NAA/Cr compared to those with EDSS less than 4 (P <0.05). Baseline cortical NAA/Cr also correlated inversely with EDSS at the 7-year follow-up (r = -0.56, P <0.05), and patients with EDSS >= 4 had a lower baseline cortical NAA/Cr compared to those with EDSS less than 4 (P <0.05). Baseline brain parenchymal fraction (BPF) correlated inversely with EDSS at month 24 (r = -0.61, P <0.05), but not with EDSS at year 7. Discussion: Cortical NAA/Cr in early RRMS correlated with clinical disability after 2 and 7 years and may be used as a predictor of long-term disease outcome.
Original languageEnglish
JournalNeurological Research
Volume36
Issue number8
Pages (from-to)701-708
ISSN0161-6412
DOIs
Publication statusPublished - 2014

Keywords

  • Primates Mammalia Vertebrata Chordata Animalia (Animals, Chordates, Humans, Mammals, Primates, Vertebrates) - Hominidae [86215] human common adult female, male
  • creatine 57-00-1
  • N-acetyl aspartate 997-55-7
  • 06504, Radiation biology - Radiation and isotope techniques
  • 10064, Biochemistry studies - Proteins, peptides and amino acids
  • 20504, Nervous system - Physiology and biochemistry
  • 20506, Nervous system - Pathology
  • 34508, Immunology - Immunopathology, tissue immunology
  • Clinical Immunology
  • Neurology
  • Radiology
  • relapsing-remitting multiple sclerosis Multiple Sclerosis, Relapsing-Remitting (MeSH) nervous system disease, immune system disease
  • clinical disability
  • Human Medicine, Medical Sciences
  • Medical Sciences
  • brain nervous system
  • clinical examination clinical techniques, diagnostic techniques
  • magnetic resonance imaging imaging and microscopy techniques, diagnostic techniques, clinical techniques
  • magnetic resonance spectroscopy laboratory techniques, spectrum analysis techniques
  • CLINICAL
  • NEUROSCIENCES
  • APPEARING WHITE-MATTER
  • MAGNETIC-RESONANCE-SPECTROSCOPY
  • AXONAL DAMAGE
  • GRAY-MATTER
  • METABOLITE CHANGES
  • GREY-MATTER
  • BRAIN
  • LESIONS
  • IMPAIRMENT
  • RELEVANCE
  • MRSI
  • MRI
  • Cortical NAA
  • Cortical choline
  • Multiple sclerosis

Cite this

Wu, X., Hanson, L. G., Skimminge, A. J. M., Sorensen, P. S., Paulson, O. B., Mathiesen, H. K., & Blinkenberg, M. (2014). Cortical N-acetyl aspartate is a predictor of long-term clinical disability in multiple sclerosis. Neurological Research, 36(8), 701-708. https://doi.org/10.1179/1743132813Y.0000000312