Cortical N-acetyl aspartate is a predictor of long-term clinical disability in multiple sclerosis

Xingchen Wu; Lars G.  Hanson; Arnold Jesper Møller Skimminge; Per Soelberg Sorensen; Olaf Bjarne Paulson; Henrik Kahr Mathiesen; Morten Blinkenberg

doi:10.1179/1743132813Y.0000000312

Cortical N-acetyl aspartate is a predictor of long-term clinical disability in multiple sclerosis

Xingchen Wu, Lars G. Hanson, Arnold Jesper Møller Skimminge, Per Soelberg Sorensen, Olaf Bjarne Paulson, Henrik Kahr Mathiesen, Morten Blinkenberg

University of Copenhagen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Objective: To evaluate the prognostic value of the cortical N-acetyl aspartate to creatine ratio (NAA/Cr) in early relapsing-remitting multiple sclerosis (RRMS). Methods: Sixteen patients with newly diagnosed RRMS were studied by serial MRI and MR spectroscopic imaging (MRSI) once every 6 months for 24 months. Clinical examinations, including the expanded disability status scale (EDSS), were performed at baseline, month 24, and at year 7. Results: Baseline cortical NAA/Cr correlated inversely with EDSS at month 24 (r = -0.61, P <0.05), and patients with EDSS >= 4 had a lower baseline cortical NAA/Cr compared to those with EDSS less than 4 (P <0.05). Baseline cortical NAA/Cr also correlated inversely with EDSS at the 7-year follow-up (r = -0.56, P <0.05), and patients with EDSS >= 4 had a lower baseline cortical NAA/Cr compared to those with EDSS less than 4 (P <0.05). Baseline brain parenchymal fraction (BPF) correlated inversely with EDSS at month 24 (r = -0.61, P <0.05), but not with EDSS at year 7. Discussion: Cortical NAA/Cr in early RRMS correlated with clinical disability after 2 and 7 years and may be used as a predictor of long-term disease outcome.

Original language	English
Journal	Neurological Research
Volume	36
Issue number	8
Pages (from-to)	701-708
ISSN	0161-6412
DOIs	https://doi.org/10.1179/1743132813Y.0000000312
Publication status	Published - 2014

Keywords

Primates Mammalia Vertebrata Chordata Animalia (Animals, Chordates, Humans, Mammals, Primates, Vertebrates) - Hominidae [86215] human common adult female, male
creatine 57-00-1
N-acetyl aspartate 997-55-7
06504, Radiation biology - Radiation and isotope techniques
10064, Biochemistry studies - Proteins, peptides and amino acids
20504, Nervous system - Physiology and biochemistry
20506, Nervous system - Pathology
34508, Immunology - Immunopathology, tissue immunology
Clinical Immunology
Neurology
Radiology
relapsing-remitting multiple sclerosis Multiple Sclerosis, Relapsing-Remitting (MeSH) nervous system disease, immune system disease
clinical disability
Human Medicine, Medical Sciences
Medical Sciences
brain nervous system
clinical examination clinical techniques, diagnostic techniques
magnetic resonance imaging imaging and microscopy techniques, diagnostic techniques, clinical techniques
magnetic resonance spectroscopy laboratory techniques, spectrum analysis techniques
CLINICAL
NEUROSCIENCES
APPEARING WHITE-MATTER
MAGNETIC-RESONANCE-SPECTROSCOPY
AXONAL DAMAGE
GRAY-MATTER
METABOLITE CHANGES
GREY-MATTER
BRAIN
LESIONS
IMPAIRMENT
RELEVANCE
MRSI
MRI
Cortical NAA
Cortical choline
Multiple sclerosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Cortical N-acetyl aspartate is a predictor of long-term clinical disability in multiple sclerosis",

abstract = "Objective: To evaluate the prognostic value of the cortical N-acetyl aspartate to creatine ratio (NAA/Cr) in early relapsing-remitting multiple sclerosis (RRMS). Methods: Sixteen patients with newly diagnosed RRMS were studied by serial MRI and MR spectroscopic imaging (MRSI) once every 6 months for 24 months. Clinical examinations, including the expanded disability status scale (EDSS), were performed at baseline, month 24, and at year 7. Results: Baseline cortical NAA/Cr correlated inversely with EDSS at month 24 (r = -0.61, P <0.05), and patients with EDSS >= 4 had a lower baseline cortical NAA/Cr compared to those with EDSS less than 4 (P <0.05). Baseline cortical NAA/Cr also correlated inversely with EDSS at the 7-year follow-up (r = -0.56, P <0.05), and patients with EDSS >= 4 had a lower baseline cortical NAA/Cr compared to those with EDSS less than 4 (P <0.05). Baseline brain parenchymal fraction (BPF) correlated inversely with EDSS at month 24 (r = -0.61, P <0.05), but not with EDSS at year 7. Discussion: Cortical NAA/Cr in early RRMS correlated with clinical disability after 2 and 7 years and may be used as a predictor of long-term disease outcome.",

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author = "Xingchen Wu and Hanson, {Lars G.} and Skimminge, {Arnold Jesper M{\o}ller} and Sorensen, {Per Soelberg} and Paulson, {Olaf Bjarne} and Mathiesen, {Henrik Kahr} and Morten Blinkenberg",

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doi = "10.1179/1743132813Y.0000000312",

language = "English",

volume = "36",

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issn = "0161-6412",

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T1 - Cortical N-acetyl aspartate is a predictor of long-term clinical disability in multiple sclerosis

AU - Wu, Xingchen

AU - Hanson, Lars G.

AU - Skimminge, Arnold Jesper Møller

AU - Sorensen, Per Soelberg

AU - Paulson, Olaf Bjarne

AU - Mathiesen, Henrik Kahr

AU - Blinkenberg, Morten

PY - 2014

Y1 - 2014

N2 - Objective: To evaluate the prognostic value of the cortical N-acetyl aspartate to creatine ratio (NAA/Cr) in early relapsing-remitting multiple sclerosis (RRMS). Methods: Sixteen patients with newly diagnosed RRMS were studied by serial MRI and MR spectroscopic imaging (MRSI) once every 6 months for 24 months. Clinical examinations, including the expanded disability status scale (EDSS), were performed at baseline, month 24, and at year 7. Results: Baseline cortical NAA/Cr correlated inversely with EDSS at month 24 (r = -0.61, P <0.05), and patients with EDSS >= 4 had a lower baseline cortical NAA/Cr compared to those with EDSS less than 4 (P <0.05). Baseline cortical NAA/Cr also correlated inversely with EDSS at the 7-year follow-up (r = -0.56, P <0.05), and patients with EDSS >= 4 had a lower baseline cortical NAA/Cr compared to those with EDSS less than 4 (P <0.05). Baseline brain parenchymal fraction (BPF) correlated inversely with EDSS at month 24 (r = -0.61, P <0.05), but not with EDSS at year 7. Discussion: Cortical NAA/Cr in early RRMS correlated with clinical disability after 2 and 7 years and may be used as a predictor of long-term disease outcome.

AB - Objective: To evaluate the prognostic value of the cortical N-acetyl aspartate to creatine ratio (NAA/Cr) in early relapsing-remitting multiple sclerosis (RRMS). Methods: Sixteen patients with newly diagnosed RRMS were studied by serial MRI and MR spectroscopic imaging (MRSI) once every 6 months for 24 months. Clinical examinations, including the expanded disability status scale (EDSS), were performed at baseline, month 24, and at year 7. Results: Baseline cortical NAA/Cr correlated inversely with EDSS at month 24 (r = -0.61, P <0.05), and patients with EDSS >= 4 had a lower baseline cortical NAA/Cr compared to those with EDSS less than 4 (P <0.05). Baseline cortical NAA/Cr also correlated inversely with EDSS at the 7-year follow-up (r = -0.56, P <0.05), and patients with EDSS >= 4 had a lower baseline cortical NAA/Cr compared to those with EDSS less than 4 (P <0.05). Baseline brain parenchymal fraction (BPF) correlated inversely with EDSS at month 24 (r = -0.61, P <0.05), but not with EDSS at year 7. Discussion: Cortical NAA/Cr in early RRMS correlated with clinical disability after 2 and 7 years and may be used as a predictor of long-term disease outcome.

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KW - creatine 57-00-1

KW - N-acetyl aspartate 997-55-7

KW - 06504, Radiation biology - Radiation and isotope techniques

KW - 10064, Biochemistry studies - Proteins, peptides and amino acids

KW - 20504, Nervous system - Physiology and biochemistry

KW - 20506, Nervous system - Pathology

KW - 34508, Immunology - Immunopathology, tissue immunology

KW - Clinical Immunology

KW - Neurology

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KW - relapsing-remitting multiple sclerosis Multiple Sclerosis, Relapsing-Remitting (MeSH) nervous system disease, immune system disease

KW - clinical disability

KW - Human Medicine, Medical Sciences

KW - Medical Sciences

KW - brain nervous system

KW - clinical examination clinical techniques, diagnostic techniques

KW - magnetic resonance imaging imaging and microscopy techniques, diagnostic techniques, clinical techniques

KW - magnetic resonance spectroscopy laboratory techniques, spectrum analysis techniques

KW - CLINICAL

KW - NEUROSCIENCES

KW - APPEARING WHITE-MATTER

KW - MAGNETIC-RESONANCE-SPECTROSCOPY

KW - AXONAL DAMAGE

KW - GRAY-MATTER

KW - METABOLITE CHANGES

KW - GREY-MATTER

KW - BRAIN

KW - LESIONS

KW - IMPAIRMENT

KW - RELEVANCE

KW - MRSI

KW - MRI

KW - Cortical NAA

KW - Cortical choline

KW - Multiple sclerosis

U2 - 10.1179/1743132813Y.0000000312

DO - 10.1179/1743132813Y.0000000312

M3 - Journal article

C2 - 24620975

SN - 0161-6412

VL - 36

SP - 701

EP - 708

JO - Neurological Research

JF - Neurological Research

IS - 8

ER -

Cortical N-acetyl aspartate is a predictor of long-term clinical disability in multiple sclerosis

Abstract

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