Abstract
In diabetes, it can become necessary to switch between pump- and pen-based insulin treatment. This switch involves a translation between rapid- and long-acting insulin analogues. In standard-of-care translation algorithms, a unit-to-unit conversion is applied. However, this simplification may not fit all individuals. In this paper, we investigate the correlation between dose-response to rapid- and long-acting insulin in the same individual, and compare the correlation across individuals. As a measure of dose-response, we estimate the insulin sensitivity in clinical data from 25 subjects with type 1 diabetes. For parameter estimation, we use maximum likelihood with a continuous-discrete extended Kalman filter and Bergman's minimal model. The results show a weak correlation between insulin sensitivity to rapid- and long-acting insulin across individuals. On this sparse data set, the analysis suggests that the standardized unit-to-unit translation between insulin analogues may not benefit all subjects.
Original language | English |
---|---|
Title of host publication | Proceedings of 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society |
Publisher | IEEE |
Publication date | 2022 |
Pages | 2240-2243 |
ISBN (Electronic) | 9781728127828 |
DOIs | |
Publication status | Published - 2022 |
Event | 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Glasgow, United Kingdom Duration: 11 Jul 2022 → 15 Jul 2022 Conference number: 44 https://ieeexplore.ieee.org/xpl/conhome/9870821/proceeding |
Conference
Conference | 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society |
---|---|
Number | 44 |
Country/Territory | United Kingdom |
City | Glasgow |
Period | 11/07/2022 → 15/07/2022 |
Sponsor | Verasonics, Inc. |
Internet address |