Correlation in Dose-Response to Rapid- and Long-Acting Insulin for People with Type 1 Diabetes

Sarah Ellinor Engell, Tinna Björk Aradóttir, Henrik Bengtsson, John Bagterp Jørgensen

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

Abstract

In diabetes, it can become necessary to switch between pump- and pen-based insulin treatment. This switch involves a translation between rapid- and long-acting insulin analogues. In standard-of-care translation algorithms, a unit-to-unit conversion is applied. However, this simplification may not fit all individuals. In this paper, we investigate the correlation between dose-response to rapid- and long-acting insulin in the same individual, and compare the correlation across individuals. As a measure of dose-response, we estimate the insulin sensitivity in clinical data from 25 subjects with type 1 diabetes. For parameter estimation, we use maximum likelihood with a continuous-discrete extended Kalman filter and Bergman's minimal model. The results show a weak correlation between insulin sensitivity to rapid- and long-acting insulin across individuals. On this sparse data set, the analysis suggests that the standardized unit-to-unit translation between insulin analogues may not benefit all subjects.

Original languageEnglish
Title of host publicationProceedings of 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
PublisherIEEE
Publication date2022
Pages2240-2243
ISBN (Electronic)9781728127828
DOIs
Publication statusPublished - 2022
Event44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Glasgow, United Kingdom
Duration: 11 Jul 202215 Jul 2022
Conference number: 44
https://ieeexplore.ieee.org/xpl/conhome/9870821/proceeding

Conference

Conference44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Number44
Country/TerritoryUnited Kingdom
CityGlasgow
Period11/07/202215/07/2022
SponsorVerasonics, Inc.
Internet address

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