Copper-free click — a promising tool for pre-targeted PET imaging

Helen L. Evans, Rozanna L. Slade, Laurence Carroll, Graham Smith, Quang-De Nguyen, Lisa Iddon, Nazila Kamaly, Henning Stöckmann, Finian J. Leeper, Eric O. Aboagye, Alan C. Spivey

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The copper-free click (CFC) reaction has been evaluated for its potential application to in vivo pre-targeting for PET imaging. A promising biodistribution profile is demonstrated when employing [18F]2-fluoroethylazide ([1818F]1) and optimisation of the CFC reaction with a series of cyclooctynes shows that reactions proceed efficiently with tantalizing opportunities for application-specific tuning.
Original languageEnglish
JournalChemical Communications
Volume48
Issue number7
Pages (from-to)991-993
ISSN1359-7345
Publication statusPublished - 2011
Externally publishedYes

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