Coplanar Electrode Layout Optimized for Increased Sensitivity for Electrical Impedance Spectroscopy

Casper Hyttel Clausen; Gustav Erik Skands; Christian Vinther Bertelsen; Winnie Edith Svendsen

doi:10.3390/mi6010110

Coplanar Electrode Layout Optimized for Increased Sensitivity for Electrical Impedance Spectroscopy

Casper Hyttel Clausen, Gustav Erik Skands, Christian Vinther Bertelsen, Winnie Edith Svendsen

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Abstract

This work describes an improvement in the layout of coplanar electrodes for electrical impedance spectroscopy. We have developed, fabricated, and tested an improved electrode layout, which improves the sensitivity of an impedance flow cytometry chip. The improved chip was experimentally tested and compared to a chip with a conventional electrode layout. The improved chip was able to discriminate 0.5 mu m beads from 1 mu m as opposed to the conventional chip. Furthermore, finite element modeling was used to simulate the improvements in electrical field density and uniformity between the electrodes of the new electrode layout. Good agreement was observed between the model and the obtained experimental results.

Original language	English
Journal	Micromachines
Volume	6
Issue number	1
Pages (from-to)	110-120
Number of pages	11
ISSN	2072-666X
DOIs	https://doi.org/10.3390/mi6010110
Publication status	Published - 2015

Bibliographical note

Creative Commons Attribution License

Keywords

Electrical impedance spectroscopy
Sensitivity
Improved design
Impedance flow cytometry

Access to Document

10.3390/mi6010110

Micromachines 06 00110Final published version, 4.4 MB

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Cite this

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title = "Coplanar Electrode Layout Optimized for Increased Sensitivity for Electrical Impedance Spectroscopy",

abstract = "This work describes an improvement in the layout of coplanar electrodes for electrical impedance spectroscopy. We have developed, fabricated, and tested an improved electrode layout, which improves the sensitivity of an impedance flow cytometry chip. The improved chip was experimentally tested and compared to a chip with a conventional electrode layout. The improved chip was able to discriminate 0.5 mu m beads from 1 mu m as opposed to the conventional chip. Furthermore, finite element modeling was used to simulate the improvements in electrical field density and uniformity between the electrodes of the new electrode layout. Good agreement was observed between the model and the obtained experimental results.",

keywords = "Electrical impedance spectroscopy, Sensitivity, Improved design, Impedance flow cytometry",

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AU - Clausen, Casper Hyttel

AU - Skands, Gustav Erik

AU - Bertelsen, Christian Vinther

AU - Svendsen, Winnie Edith

N1 - Creative Commons Attribution License

PY - 2015

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N2 - This work describes an improvement in the layout of coplanar electrodes for electrical impedance spectroscopy. We have developed, fabricated, and tested an improved electrode layout, which improves the sensitivity of an impedance flow cytometry chip. The improved chip was experimentally tested and compared to a chip with a conventional electrode layout. The improved chip was able to discriminate 0.5 mu m beads from 1 mu m as opposed to the conventional chip. Furthermore, finite element modeling was used to simulate the improvements in electrical field density and uniformity between the electrodes of the new electrode layout. Good agreement was observed between the model and the obtained experimental results.

AB - This work describes an improvement in the layout of coplanar electrodes for electrical impedance spectroscopy. We have developed, fabricated, and tested an improved electrode layout, which improves the sensitivity of an impedance flow cytometry chip. The improved chip was experimentally tested and compared to a chip with a conventional electrode layout. The improved chip was able to discriminate 0.5 mu m beads from 1 mu m as opposed to the conventional chip. Furthermore, finite element modeling was used to simulate the improvements in electrical field density and uniformity between the electrodes of the new electrode layout. Good agreement was observed between the model and the obtained experimental results.

KW - Electrical impedance spectroscopy

KW - Sensitivity

KW - Improved design

KW - Impedance flow cytometry

U2 - 10.3390/mi6010110

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