Convergent Total Synthesis of Exochelin 772SM

Charlotte Uldahl Jansen, Amalie Nørskov, Kim T Mortensen, Katrine M Qvortrup*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review


A convergent total synthesis of the natural mycobacterial iron chelator desferri-exochelin 772SM (D-EXO) is described. The synthetic procedure proceeds in 11 steps in the longest linear sequence, with an overall yield of 8.6%. The described procedure uses cheap starting materials and requires a limited number of chromatographic purifications. The concise strategy divides the exochelin into five key building blocks, allowing easy alternation of each single building block. Herein, the presented synthetic strategy is well suited to facilitate the synthesis of analogues and medicinal chemistry development efforts in a time- and resource-efficient manner.
Original languageEnglish
JournalJournal of organic chemistry
Issue number13
Pages (from-to)8669–8673
Publication statusPublished - 2023


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