Convenient one-step synthesis of 5-carboxy-seminaphthofluoresceins

Peter Hammershøj, Erling Thyhaug, Pernille Harris, Pramod Kumar Ek, Thomas Lars Andresen, Mads Hartvig Clausen

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

The one-step synthesis and characterization of a series of regioisomerically pure 5-carboxy-seminaphthofluoresceins (5-carboxy-SNAFLs) is reported. The optical properties were determined in aqueous buffer at around biological pH, and highly pH sensitive, large Stokes-shift fluorophores with emission in the deep-red to near-infrared region were identified
Original languageEnglish
JournalTetrahedron Letters
Volume58
Issue number16
Pages (from-to)1611-1615
ISSN0040-4039
DOIs
Publication statusPublished - 2017

Keywords

  • 5-Carboxy-seminaphthofluoresceins
  • Near-infrared-emitter
  • One-step synthesis
  • Enhanced Stokes shifts

Cite this

Hammershøj, Peter ; Thyhaug, Erling ; Harris, Pernille ; Ek, Pramod Kumar ; Andresen, Thomas Lars ; Clausen, Mads Hartvig. / Convenient one-step synthesis of 5-carboxy-seminaphthofluoresceins. In: Tetrahedron Letters. 2017 ; Vol. 58, No. 16. pp. 1611-1615.
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abstract = "The one-step synthesis and characterization of a series of regioisomerically pure 5-carboxy-seminaphthofluoresceins (5-carboxy-SNAFLs) is reported. The optical properties were determined in aqueous buffer at around biological pH, and highly pH sensitive, large Stokes-shift fluorophores with emission in the deep-red to near-infrared region were identified",
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Convenient one-step synthesis of 5-carboxy-seminaphthofluoresceins. / Hammershøj, Peter; Thyhaug, Erling; Harris, Pernille; Ek, Pramod Kumar; Andresen, Thomas Lars; Clausen, Mads Hartvig.

In: Tetrahedron Letters, Vol. 58, No. 16, 2017, p. 1611-1615.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Convenient one-step synthesis of 5-carboxy-seminaphthofluoresceins

AU - Hammershøj, Peter

AU - Thyhaug, Erling

AU - Harris, Pernille

AU - Ek, Pramod Kumar

AU - Andresen, Thomas Lars

AU - Clausen, Mads Hartvig

PY - 2017

Y1 - 2017

N2 - The one-step synthesis and characterization of a series of regioisomerically pure 5-carboxy-seminaphthofluoresceins (5-carboxy-SNAFLs) is reported. The optical properties were determined in aqueous buffer at around biological pH, and highly pH sensitive, large Stokes-shift fluorophores with emission in the deep-red to near-infrared region were identified

AB - The one-step synthesis and characterization of a series of regioisomerically pure 5-carboxy-seminaphthofluoresceins (5-carboxy-SNAFLs) is reported. The optical properties were determined in aqueous buffer at around biological pH, and highly pH sensitive, large Stokes-shift fluorophores with emission in the deep-red to near-infrared region were identified

KW - 5-Carboxy-seminaphthofluoresceins

KW - Near-infrared-emitter

KW - One-step synthesis

KW - Enhanced Stokes shifts

U2 - 10.1016/j.tetlet.2017.03.028

DO - 10.1016/j.tetlet.2017.03.028

M3 - Journal article

VL - 58

SP - 1611

EP - 1615

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 16

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