Convenient one-step synthesis of 5-carboxy-seminaphthofluoresceins

Peter Hammershøj, Erling Thyhaug, Pernille Harris, Pramod Kumar Ek, Thomas Lars Andresen, Mads Hartvig Clausen

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The one-step synthesis and characterization of a series of regioisomerically pure 5-carboxy-seminaphthofluoresceins (5-carboxy-SNAFLs) is reported. The optical properties were determined in aqueous buffer at around biological pH, and highly pH sensitive, large Stokes-shift fluorophores with emission in the deep-red to near-infrared region were identified
Original languageEnglish
JournalTetrahedron Letters
Issue number16
Pages (from-to)1611-1615
Publication statusPublished - 2017


  • 5-Carboxy-seminaphthofluoresceins
  • Near-infrared-emitter
  • One-step synthesis
  • Enhanced Stokes shifts

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