Convenient one-step synthesis of 5-carboxy-seminaphthofluoresceins

Peter Hammershøj; Erling Thyhaug; Pernille Harris; Pramod Kumar Ek; Thomas Lars Andresen; Mads Hartvig Clausen

doi:10.1016/j.tetlet.2017.03.028

Convenient one-step synthesis of 5-carboxy-seminaphthofluoresceins

Peter Hammershøj, Erling Thyhaug, Pernille Harris, Pramod Kumar Ek, Thomas Lars Andresen, Mads Hartvig Clausen

Lund University

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Abstract

The one-step synthesis and characterization of a series of regioisomerically pure 5-carboxy-seminaphthofluoresceins (5-carboxy-SNAFLs) is reported. The optical properties were determined in aqueous buffer at around biological pH, and highly pH sensitive, large Stokes-shift fluorophores with emission in the deep-red to near-infrared region were identified

Original language	English
Journal	Tetrahedron Letters
Volume	58
Issue number	16
Pages (from-to)	1611-1615
ISSN	0040-4039
DOIs	https://doi.org/10.1016/j.tetlet.2017.03.028
Publication status	Published - 2017

Keywords

5-Carboxy-seminaphthofluoresceins
Near-infrared-emitter
One-step synthesis
Enhanced Stokes shifts

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10.1016/j.tetlet.2017.03.028

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abstract = "The one-step synthesis and characterization of a series of regioisomerically pure 5-carboxy-seminaphthofluoresceins (5-carboxy-SNAFLs) is reported. The optical properties were determined in aqueous buffer at around biological pH, and highly pH sensitive, large Stokes-shift fluorophores with emission in the deep-red to near-infrared region were identified",

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AU - Hammershøj, Peter

AU - Thyhaug, Erling

AU - Harris, Pernille

AU - Ek, Pramod Kumar

AU - Andresen, Thomas Lars

AU - Clausen, Mads Hartvig

PY - 2017

Y1 - 2017

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AB - The one-step synthesis and characterization of a series of regioisomerically pure 5-carboxy-seminaphthofluoresceins (5-carboxy-SNAFLs) is reported. The optical properties were determined in aqueous buffer at around biological pH, and highly pH sensitive, large Stokes-shift fluorophores with emission in the deep-red to near-infrared region were identified

KW - 5-Carboxy-seminaphthofluoresceins

KW - Near-infrared-emitter

KW - One-step synthesis

KW - Enhanced Stokes shifts

U2 - 10.1016/j.tetlet.2017.03.028

DO - 10.1016/j.tetlet.2017.03.028

M3 - Journal article

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EP - 1615

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 16

ER -

Convenient one-step synthesis of 5-carboxy-seminaphthofluoresceins

Abstract

Keywords

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