Controlled release of chol-TEG-DNA from nano- and micropatterned SU-8 surfaces by a spreading lipid film

Yavuz Erkan; Kiona Halma; Ilja Czolkos; Aldo Jesorka; Paul Dommersnes; Ravindra Kumar; Tom Brown; Owe Orwar

doi:10.1021/nl0725087

Controlled release of chol-TEG-DNA from nano- and micropatterned SU-8 surfaces by a spreading lipid film

Yavuz Erkan, Kiona Halma, Ilja Czolkos, Aldo Jesorka, Paul Dommersnes, Ravindra Kumar, Tom Brown, Owe Orwar

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

We report the controlled release of immobilized cholesteryl- tetraethyleneglycol-DNA (chol-DNA) from micropatterned SU-8 surfaces by a spreading lipid film. The release of chol-DNA is rapid and on the order of the spreading rate of the lipid film β = 1-3 μ2/s (∼M 5 molecules of DNA per second). The lipid film serves as a poor solvent for the DNA adduct, which upon contact redistributes into the aqueous phase. Thus, the release of DNA is accompanied by a change in surface hydrophobicity. The method can be used for creating arbitrary concentration profiles of DNA in solution over time or to dynamically change surface properties on demand in, for example, micro- and nanofluidic devices. Examples of DNA release from spiral, comb, meander, and triangular as well as from nanoscale SU-8 lanes are shown. © 2008 American Chemical Society.

Original language	English
Journal	Nano Letters
Volume	8
Issue number	1
Pages (from-to)	227-231
ISSN	1530-6984
DOIs	https://doi.org/10.1021/nl0725087
Publication status	Published - 2008
Externally published	Yes

Access to Document

10.1021/nl0725087

OpenUrl availability

Full text

Cite this

@article{cad78f0627634109b385d4ab5cd75c09,

title = "Controlled release of chol-TEG-DNA from nano- and micropatterned SU-8 surfaces by a spreading lipid film",

abstract = "We report the controlled release of immobilized cholesteryl- tetraethyleneglycol-DNA (chol-DNA) from micropatterned SU-8 surfaces by a spreading lipid film. The release of chol-DNA is rapid and on the order of the spreading rate of the lipid film β = 1-3 μ2/s (∼M 5 molecules of DNA per second). The lipid film serves as a poor solvent for the DNA adduct, which upon contact redistributes into the aqueous phase. Thus, the release of DNA is accompanied by a change in surface hydrophobicity. The method can be used for creating arbitrary concentration profiles of DNA in solution over time or to dynamically change surface properties on demand in, for example, micro- and nanofluidic devices. Examples of DNA release from spiral, comb, meander, and triangular as well as from nanoscale SU-8 lanes are shown. {\textcopyright} 2008 American Chemical Society.",

author = "Yavuz Erkan and Kiona Halma and Ilja Czolkos and Aldo Jesorka and Paul Dommersnes and Ravindra Kumar and Tom Brown and Owe Orwar",

year = "2008",

doi = "10.1021/nl0725087",

language = "English",

volume = "8",

pages = "227--231",

journal = "Nano Letters",

issn = "1530-6984",

publisher = "American Chemical Society",

number = "1",

}

TY - JOUR

T1 - Controlled release of chol-TEG-DNA from nano- and micropatterned SU-8 surfaces by a spreading lipid film

AU - Erkan, Yavuz

AU - Halma, Kiona

AU - Czolkos, Ilja

AU - Jesorka, Aldo

AU - Dommersnes, Paul

AU - Kumar, Ravindra

AU - Brown, Tom

AU - Orwar, Owe

PY - 2008

Y1 - 2008

N2 - We report the controlled release of immobilized cholesteryl- tetraethyleneglycol-DNA (chol-DNA) from micropatterned SU-8 surfaces by a spreading lipid film. The release of chol-DNA is rapid and on the order of the spreading rate of the lipid film β = 1-3 μ2/s (∼M 5 molecules of DNA per second). The lipid film serves as a poor solvent for the DNA adduct, which upon contact redistributes into the aqueous phase. Thus, the release of DNA is accompanied by a change in surface hydrophobicity. The method can be used for creating arbitrary concentration profiles of DNA in solution over time or to dynamically change surface properties on demand in, for example, micro- and nanofluidic devices. Examples of DNA release from spiral, comb, meander, and triangular as well as from nanoscale SU-8 lanes are shown. © 2008 American Chemical Society.

AB - We report the controlled release of immobilized cholesteryl- tetraethyleneglycol-DNA (chol-DNA) from micropatterned SU-8 surfaces by a spreading lipid film. The release of chol-DNA is rapid and on the order of the spreading rate of the lipid film β = 1-3 μ2/s (∼M 5 molecules of DNA per second). The lipid film serves as a poor solvent for the DNA adduct, which upon contact redistributes into the aqueous phase. Thus, the release of DNA is accompanied by a change in surface hydrophobicity. The method can be used for creating arbitrary concentration profiles of DNA in solution over time or to dynamically change surface properties on demand in, for example, micro- and nanofluidic devices. Examples of DNA release from spiral, comb, meander, and triangular as well as from nanoscale SU-8 lanes are shown. © 2008 American Chemical Society.

U2 - 10.1021/nl0725087

DO - 10.1021/nl0725087

M3 - Journal article

C2 - 18069872

SN - 1530-6984

VL - 8

SP - 227

EP - 231

JO - Nano Letters

JF - Nano Letters

IS - 1

ER -

Controlled release of chol-TEG-DNA from nano- and micropatterned SU-8 surfaces by a spreading lipid film

Abstract

Access to Document

OpenUrl availability

Fingerprint

Cite this