Controlled Drug Release from Biodegradable Polymer Matrix Loaded in Microcontainers Using Hot Punching

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Abstract

Microcontainers are reservoir-based advanced drug delivery systems (DDS) that have proven to increase the bioavailibity of the small-molecule drugs, targeting of biomolecules, protection of vaccines and improved treatment of Pseudomonas aeruginosa. However, high-throughput loading of these micron-sized devices with drug has been challenging. Hot punching is a new technique that is a fast, simple and single-step process where the microdevices are themselves used as mold to punch biocompatible and biodegradable drug-polymer films, thereby loading the containers. Here, we investigate the effect of hot punching on the drug distribution as well as drug release from the loaded drug-polymer matrices. Zero-order sustained drug release is observed for the model drug Furosemide embedded in biodegradable polymer, Poly-ε-caprolactone, which is attributed to the unique spatial distribution of Furosemide during the loading process.
Original languageEnglish
Article number1050
JournalPharmaceutics
Volume12
Issue number11
Number of pages13
ISSN1999-4923
DOIs
Publication statusPublished - 2020

Keywords

  • Biocompatible and biodegradable polymer
  • Hot punching
  • Oral drug delivery
  • Spin coating
  • Controlled release
  • Zero-order

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