Abstract
Since continuous glucose monitoring (CGM) technology and insulin pumps have improved recent
years, a strong interest in a closed-loop articial pancreas for people with type 1 diabetes has
arisen. Presently, a fully automated controller of blood glucose must face many challenges, such
as daily variations of patient's physiology and lack of accuracy of glucose sensors. In this paper
we design and discuss an algorithm for overnight closed-loop control of blood glucose in people
with type 1 diabetes. The algorithm is based on Model Predictive Control (MPC). We use an
oset-free autoregressive model with exogenous input and moving average (ARMAX) to model
the patient. Observer design and a time-varying glucose reference signal improve robustness of
the algorithm. We test the algorithm in two clinical studies conducted at Hvidovre Hospital.
The rst study took place overnight, and the second one took place during daytime. These trials
demonstrate the importance of observer design in ARMAX models and show the possibility of
stabilizing blood glucose during the night.
Original language | English |
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Title of host publication | Proceedings of the 17th Nordic Process Control Workshop |
Editors | John Bagterp Jørgensen, Jakob Kjøbsted Huusom, Gürkan Sin |
Place of Publication | Kogens Lyngby |
Publisher | Technical University of Denmark |
Publication date | 2012 |
Pages | 133-140 |
ISBN (Print) | 978-87-643-0946-1 |
Publication status | Published - 2012 |
Event | 17th Nordic Process Control Workshop - Kongens Lyngby, Denmark Duration: 25 Jan 2012 → 27 Jan 2012 Conference number: 17 http://npcw17.imm.dtu.dk/ |
Conference
Conference | 17th Nordic Process Control Workshop |
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Number | 17 |
Country/Territory | Denmark |
City | Kongens Lyngby |
Period | 25/01/2012 → 27/01/2012 |
Internet address |