Continuing occurrence of vancomycin resistance determinants in Danish pig farms 20 years after removing exposure to avoparcin

Anna Camilla Birkegård, Kaare Græsbøll, Julie Clasen, Tariq Halasa, Nils Toft, Anders Folkesson*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Vancomycin-resistant Enterococcus spp. is a major health problem worldwide and livestock have been implicated in constituting a reservoir for the transmission of vancomycin resistance to zoonotic pathogens. Vancomycin resistance determinants can be situated on mobile genetic elements and transferred between bacterial species The livestock reservoir must therefore be included in a risk assessment of the vancomycin resistance burden. Avoparcin, a vancomycin analogue, has not been used in Danish pig production for over 20 years and vancomycin has never been used. The objective of this study was to screen faecal samples from Danish pig farms for nine selected vancomycin resistance determinants. We found at least four different vancomycin resistance determinants in all screened Danish pig farms (665 finisher farms and 78 sow farms). The vancomycin resistance determinants present in vanB or vanG clusters were found at significantly different levels in sow and finisher farms. However, vanA was not detected in any of the farms. In conclusion, vancomycin resistance determinants are still present in Danish pig production 25 years after the ban on avoparcin use.

Original languageEnglish
JournalVeterinary Microbiology
Volume232
Pages (from-to)84-88
Number of pages5
ISSN0378-1135
DOIs
Publication statusPublished - 2019

Keywords

  • Antimicrobial resistance
  • Avoparcin
  • Glycopeptides
  • Swine

Cite this

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title = "Continuing occurrence of vancomycin resistance determinants in Danish pig farms 20 years after removing exposure to avoparcin",
abstract = "Vancomycin-resistant Enterococcus spp. is a major health problem worldwide and livestock have been implicated in constituting a reservoir for the transmission of vancomycin resistance to zoonotic pathogens. Vancomycin resistance determinants can be situated on mobile genetic elements and transferred between bacterial species The livestock reservoir must therefore be included in a risk assessment of the vancomycin resistance burden. Avoparcin, a vancomycin analogue, has not been used in Danish pig production for over 20 years and vancomycin has never been used. The objective of this study was to screen faecal samples from Danish pig farms for nine selected vancomycin resistance determinants. We found at least four different vancomycin resistance determinants in all screened Danish pig farms (665 finisher farms and 78 sow farms). The vancomycin resistance determinants present in vanB or vanG clusters were found at significantly different levels in sow and finisher farms. However, vanA was not detected in any of the farms. In conclusion, vancomycin resistance determinants are still present in Danish pig production 25 years after the ban on avoparcin use.",
keywords = "Antimicrobial resistance, Avoparcin, Glycopeptides, Swine",
author = "Birkeg{\aa}rd, {Anna Camilla} and Kaare Gr{\ae}sb{\o}ll and Julie Clasen and Tariq Halasa and Nils Toft and Anders Folkesson",
year = "2019",
doi = "10.1016/j.vetmic.2019.04.007",
language = "English",
volume = "232",
pages = "84--88",
journal = "Veterinary Microbiology",
issn = "0378-1135",
publisher = "Elsevier",

}

Continuing occurrence of vancomycin resistance determinants in Danish pig farms 20 years after removing exposure to avoparcin. / Birkegård, Anna Camilla; Græsbøll, Kaare; Clasen, Julie; Halasa, Tariq; Toft, Nils; Folkesson, Anders.

In: Veterinary Microbiology, Vol. 232, 2019, p. 84-88.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Continuing occurrence of vancomycin resistance determinants in Danish pig farms 20 years after removing exposure to avoparcin

AU - Birkegård, Anna Camilla

AU - Græsbøll, Kaare

AU - Clasen, Julie

AU - Halasa, Tariq

AU - Toft, Nils

AU - Folkesson, Anders

PY - 2019

Y1 - 2019

N2 - Vancomycin-resistant Enterococcus spp. is a major health problem worldwide and livestock have been implicated in constituting a reservoir for the transmission of vancomycin resistance to zoonotic pathogens. Vancomycin resistance determinants can be situated on mobile genetic elements and transferred between bacterial species The livestock reservoir must therefore be included in a risk assessment of the vancomycin resistance burden. Avoparcin, a vancomycin analogue, has not been used in Danish pig production for over 20 years and vancomycin has never been used. The objective of this study was to screen faecal samples from Danish pig farms for nine selected vancomycin resistance determinants. We found at least four different vancomycin resistance determinants in all screened Danish pig farms (665 finisher farms and 78 sow farms). The vancomycin resistance determinants present in vanB or vanG clusters were found at significantly different levels in sow and finisher farms. However, vanA was not detected in any of the farms. In conclusion, vancomycin resistance determinants are still present in Danish pig production 25 years after the ban on avoparcin use.

AB - Vancomycin-resistant Enterococcus spp. is a major health problem worldwide and livestock have been implicated in constituting a reservoir for the transmission of vancomycin resistance to zoonotic pathogens. Vancomycin resistance determinants can be situated on mobile genetic elements and transferred between bacterial species The livestock reservoir must therefore be included in a risk assessment of the vancomycin resistance burden. Avoparcin, a vancomycin analogue, has not been used in Danish pig production for over 20 years and vancomycin has never been used. The objective of this study was to screen faecal samples from Danish pig farms for nine selected vancomycin resistance determinants. We found at least four different vancomycin resistance determinants in all screened Danish pig farms (665 finisher farms and 78 sow farms). The vancomycin resistance determinants present in vanB or vanG clusters were found at significantly different levels in sow and finisher farms. However, vanA was not detected in any of the farms. In conclusion, vancomycin resistance determinants are still present in Danish pig production 25 years after the ban on avoparcin use.

KW - Antimicrobial resistance

KW - Avoparcin

KW - Glycopeptides

KW - Swine

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SP - 84

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JO - Veterinary Microbiology

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