Consumption of individual saturated fatty acids and the risk of myocardial infarction in a UK and a Danish cohort

Jaike Praagman, Linda E T Vissers, Angela A Mulligan, Anne Sofie Dam Laursen, Joline W J Beulens, Yvonne T van der Schouw, Nicholas J Wareham, Camilla Plambeck Hansen, Kay-Tee Khaw, Marianne Uhre Jakobsen, Ivonne Sluijs*

*Corresponding author for this work

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Abstract

The effect of individual saturated fatty acids (SFAs) on serum cholesterol levels depends on their carbon-chain length. Whether the association with myocardial infarction (MI) also differs across individual SFAs is unclear. We examined the association between consumption of individual SFAs, differing in chain lengths ranging from 4 through 18 carbons, and risk of MI. We used data from 22,050 and 53,375 participants from EPIC-Norfolk (UK) and EPIC-Denmark, respectively. Baseline SFA intakes were assessed through validated, country-specific food frequency questionnaires. Cox regression analysis was used to estimate associations between intakes of individual SFAs and MI risk, for each cohort separately. During median follow-up times of 18.8 years in EPIC-Norfolk and 13.6 years in Denmark, respectively, 1204 and 2260 MI events occurred. Mean (±SD) total SFA intake was 13.3 (±3.5) en% in EPIC-Norfolk, and 12.5 (±2.6) en% in EPIC-Denmark. After multivariable adjustment, intakes of C12:0 (lauric acid) and C14:0 (myristic acid) inversely associated with MI risk in EPIC-Denmark (HR upper versus lowest quintile: 0.80 (95%CI: 0.66, 0.96) for both SFAs). Intakes in the third and fourth quintiles of C4:0-C10:0 also associated with lower MI risk in EPIC-Denmark. Moreover, substitution of C16:0 (palmitic acid) and C18:0 (stearic acid) with plant proteins resulted in a reduction of MI risk in EPIC-Denmark (HR per 1 energy%: 0.86 (95%CI: 0.78, 0.95) and 0.87 (95%CI: 0.79, 0.96) respectively). No such associations were found in EPIC-Norfolk. The results from the present study suggest that the association between SFA and MI risk depends on the carbon chain-length of the SFA.
Original languageEnglish
JournalInternational Journal of Cardiology
Volume279
Pages (from-to)18-26
ISSN0167-5273
DOIs
Publication statusPublished - 2019

Keywords

  • Cohort study
  • Diet
  • Myocardial infarction
  • Saturated fatty acids

Cite this

Praagman, J., Vissers, L. E. T., Mulligan, A. A., Laursen, A. S. D., Beulens, J. W. J., van der Schouw, Y. T., ... Sluijs, I. (2019). Consumption of individual saturated fatty acids and the risk of myocardial infarction in a UK and a Danish cohort. International Journal of Cardiology, 279, 18-26. https://doi.org/10.1016/j.ijcard.2018.10.064
Praagman, Jaike ; Vissers, Linda E T ; Mulligan, Angela A ; Laursen, Anne Sofie Dam ; Beulens, Joline W J ; van der Schouw, Yvonne T ; Wareham, Nicholas J ; Hansen, Camilla Plambeck ; Khaw, Kay-Tee ; Jakobsen, Marianne Uhre ; Sluijs, Ivonne. / Consumption of individual saturated fatty acids and the risk of myocardial infarction in a UK and a Danish cohort. In: International Journal of Cardiology. 2019 ; Vol. 279. pp. 18-26.
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title = "Consumption of individual saturated fatty acids and the risk of myocardial infarction in a UK and a Danish cohort",
abstract = "The effect of individual saturated fatty acids (SFAs) on serum cholesterol levels depends on their carbon-chain length. Whether the association with myocardial infarction (MI) also differs across individual SFAs is unclear. We examined the association between consumption of individual SFAs, differing in chain lengths ranging from 4 through 18 carbons, and risk of MI. We used data from 22,050 and 53,375 participants from EPIC-Norfolk (UK) and EPIC-Denmark, respectively. Baseline SFA intakes were assessed through validated, country-specific food frequency questionnaires. Cox regression analysis was used to estimate associations between intakes of individual SFAs and MI risk, for each cohort separately. During median follow-up times of 18.8 years in EPIC-Norfolk and 13.6 years in Denmark, respectively, 1204 and 2260 MI events occurred. Mean (±SD) total SFA intake was 13.3 (±3.5) en{\%} in EPIC-Norfolk, and 12.5 (±2.6) en{\%} in EPIC-Denmark. After multivariable adjustment, intakes of C12:0 (lauric acid) and C14:0 (myristic acid) inversely associated with MI risk in EPIC-Denmark (HR upper versus lowest quintile: 0.80 (95{\%}CI: 0.66, 0.96) for both SFAs). Intakes in the third and fourth quintiles of C4:0-C10:0 also associated with lower MI risk in EPIC-Denmark. Moreover, substitution of C16:0 (palmitic acid) and C18:0 (stearic acid) with plant proteins resulted in a reduction of MI risk in EPIC-Denmark (HR per 1 energy{\%}: 0.86 (95{\%}CI: 0.78, 0.95) and 0.87 (95{\%}CI: 0.79, 0.96) respectively). No such associations were found in EPIC-Norfolk. The results from the present study suggest that the association between SFA and MI risk depends on the carbon chain-length of the SFA.",
keywords = "Cohort study, Diet, Myocardial infarction, Saturated fatty acids",
author = "Jaike Praagman and Vissers, {Linda E T} and Mulligan, {Angela A} and Laursen, {Anne Sofie Dam} and Beulens, {Joline W J} and {van der Schouw}, {Yvonne T} and Wareham, {Nicholas J} and Hansen, {Camilla Plambeck} and Kay-Tee Khaw and Jakobsen, {Marianne Uhre} and Ivonne Sluijs",
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Praagman, J, Vissers, LET, Mulligan, AA, Laursen, ASD, Beulens, JWJ, van der Schouw, YT, Wareham, NJ, Hansen, CP, Khaw, K-T, Jakobsen, MU & Sluijs, I 2019, 'Consumption of individual saturated fatty acids and the risk of myocardial infarction in a UK and a Danish cohort', International Journal of Cardiology, vol. 279, pp. 18-26. https://doi.org/10.1016/j.ijcard.2018.10.064

Consumption of individual saturated fatty acids and the risk of myocardial infarction in a UK and a Danish cohort. / Praagman, Jaike; Vissers, Linda E T; Mulligan, Angela A; Laursen, Anne Sofie Dam; Beulens, Joline W J; van der Schouw, Yvonne T; Wareham, Nicholas J; Hansen, Camilla Plambeck; Khaw, Kay-Tee; Jakobsen, Marianne Uhre; Sluijs, Ivonne.

In: International Journal of Cardiology, Vol. 279, 2019, p. 18-26.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Consumption of individual saturated fatty acids and the risk of myocardial infarction in a UK and a Danish cohort

AU - Praagman, Jaike

AU - Vissers, Linda E T

AU - Mulligan, Angela A

AU - Laursen, Anne Sofie Dam

AU - Beulens, Joline W J

AU - van der Schouw, Yvonne T

AU - Wareham, Nicholas J

AU - Hansen, Camilla Plambeck

AU - Khaw, Kay-Tee

AU - Jakobsen, Marianne Uhre

AU - Sluijs, Ivonne

PY - 2019

Y1 - 2019

N2 - The effect of individual saturated fatty acids (SFAs) on serum cholesterol levels depends on their carbon-chain length. Whether the association with myocardial infarction (MI) also differs across individual SFAs is unclear. We examined the association between consumption of individual SFAs, differing in chain lengths ranging from 4 through 18 carbons, and risk of MI. We used data from 22,050 and 53,375 participants from EPIC-Norfolk (UK) and EPIC-Denmark, respectively. Baseline SFA intakes were assessed through validated, country-specific food frequency questionnaires. Cox regression analysis was used to estimate associations between intakes of individual SFAs and MI risk, for each cohort separately. During median follow-up times of 18.8 years in EPIC-Norfolk and 13.6 years in Denmark, respectively, 1204 and 2260 MI events occurred. Mean (±SD) total SFA intake was 13.3 (±3.5) en% in EPIC-Norfolk, and 12.5 (±2.6) en% in EPIC-Denmark. After multivariable adjustment, intakes of C12:0 (lauric acid) and C14:0 (myristic acid) inversely associated with MI risk in EPIC-Denmark (HR upper versus lowest quintile: 0.80 (95%CI: 0.66, 0.96) for both SFAs). Intakes in the third and fourth quintiles of C4:0-C10:0 also associated with lower MI risk in EPIC-Denmark. Moreover, substitution of C16:0 (palmitic acid) and C18:0 (stearic acid) with plant proteins resulted in a reduction of MI risk in EPIC-Denmark (HR per 1 energy%: 0.86 (95%CI: 0.78, 0.95) and 0.87 (95%CI: 0.79, 0.96) respectively). No such associations were found in EPIC-Norfolk. The results from the present study suggest that the association between SFA and MI risk depends on the carbon chain-length of the SFA.

AB - The effect of individual saturated fatty acids (SFAs) on serum cholesterol levels depends on their carbon-chain length. Whether the association with myocardial infarction (MI) also differs across individual SFAs is unclear. We examined the association between consumption of individual SFAs, differing in chain lengths ranging from 4 through 18 carbons, and risk of MI. We used data from 22,050 and 53,375 participants from EPIC-Norfolk (UK) and EPIC-Denmark, respectively. Baseline SFA intakes were assessed through validated, country-specific food frequency questionnaires. Cox regression analysis was used to estimate associations between intakes of individual SFAs and MI risk, for each cohort separately. During median follow-up times of 18.8 years in EPIC-Norfolk and 13.6 years in Denmark, respectively, 1204 and 2260 MI events occurred. Mean (±SD) total SFA intake was 13.3 (±3.5) en% in EPIC-Norfolk, and 12.5 (±2.6) en% in EPIC-Denmark. After multivariable adjustment, intakes of C12:0 (lauric acid) and C14:0 (myristic acid) inversely associated with MI risk in EPIC-Denmark (HR upper versus lowest quintile: 0.80 (95%CI: 0.66, 0.96) for both SFAs). Intakes in the third and fourth quintiles of C4:0-C10:0 also associated with lower MI risk in EPIC-Denmark. Moreover, substitution of C16:0 (palmitic acid) and C18:0 (stearic acid) with plant proteins resulted in a reduction of MI risk in EPIC-Denmark (HR per 1 energy%: 0.86 (95%CI: 0.78, 0.95) and 0.87 (95%CI: 0.79, 0.96) respectively). No such associations were found in EPIC-Norfolk. The results from the present study suggest that the association between SFA and MI risk depends on the carbon chain-length of the SFA.

KW - Cohort study

KW - Diet

KW - Myocardial infarction

KW - Saturated fatty acids

U2 - 10.1016/j.ijcard.2018.10.064

DO - 10.1016/j.ijcard.2018.10.064

M3 - Journal article

VL - 279

SP - 18

EP - 26

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

ER -