Abstract
Two simple, mechanical modifications are introduced to a consumer-grade inkjet printer to greatly increase its applicability. First, roller isolation bars are added to unlock multiple prints on the same substrate without smearing. This enables printing on a diverse set of substrates (rigid, elastic, liquid, granular, and sticky). Second, spring loadings are added to increase the print precision up to 50-fold, which facilitates alignment to a pre-patterned substrate or between successive prints. Utilizing the expanded substrate compatibility and the increased print precision, we explore tunable loading of drug combinations into microdevices. This loading method has promising applications within point-of-care personalized medication. Furthermore, we show how inkjet printers with array-type printheads (in our case, 6 x 90 nozzles) allow for quasi-simultaneous loading of reactants into microfluidic systems. The ability to do a quasi-simultaneous introduction of chemicals may be particularly useful for studies of rapidly reacting systems of three or more reactants, where premature introduction can shift the initial conditions from the intended. We believe that our modifications to an affordable system will inspire researchers to explore the possibilities of inkjet printing even further.
| Original language | English |
|---|---|
| Journal | ACS Omega |
| Volume | 6 |
| Issue number | 11 |
| Pages (from-to) | 7786-7794 |
| DOIs | |
| Publication status | Published - 2021 |
Bibliographical note
Funding Information:The authors would like to acknowledge the financial support from the Danish National Research Foundation (DNRF122), Villum Foundation (grant no. 9301) for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics (IDUN), and the Novo Nordisk Foundation (NNF17OC0026910)—Microstructures, microbiota and oral delivery (MIMIO). N.K.M. is supported by an Excellence Ph.D. Scholarship from DTU Health Tech. The authors would also like to thank Lasse Højlund Eklund Thamdrup from the Department of Health Technology, Technical University of Denmark, for his help with the preparation of the microcontainers. Furthermore, the authors acknowledge the help from Lars Schulte for printer debugging; Daniel Andre Bunckenburg for assistance at the drug loading demonstration; and Anders Meyer Torp, Stine Egebro Hansen, and Priscila Guerra for input and help with the idea about screening for combinatorial minimum inhibition concentrations.
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