Constructs, compositions and methods thereof having improved genome editing efficiency and specificity

Ryan Gill (Inventor), Tanya Warnecke (Inventor), Dominika Jedrzejczyk (Inventor)

Research output: Patent

7 Downloads (Pure)

Abstract

Embodiments disclosed herein include novel nucleic acid-guided nucleases, novel guide nucleic acids, and novel targetable nuclease systems, and methods of use. In some embodiments, engineered non-naturally occurring nucleic acid-guided nucleases, can be used with known guide nucleic acids in a targetable nuclease system. In certain embodiments, targetable nuclease systems can be used to edit targeted genomes of humans and other species. In some embodiments, methods include, but are not limited to, recursive genetic engineering and trackable genetic engineering methods.

Original languageEnglish
IPCC12N 15/ 90 A I
Patent numberWO2021108324
Filing date23/11/2020
Country/TerritoryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date27/11/2019
Priority numberUS201962941392P
Publication statusPublished - 3 Jun 2021

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