Construction of the simplest model to explain complex receptor activation kinetics

RP Bywater; A Sorensen; Peter Røgen; Poul G. Hjorth

Construction of the simplest model to explain complex receptor activation kinetics

RP Bywater, A Sorensen, Peter Røgen, Poul G. Hjorth

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

We study the mathematical solutions to the kinetic equations arising from various simple ligand-reactor models. Focusing on the prediction of the various models for the activity vs. concentration curve, we find that solutions to the kinetic equations arising from the so-called dimer model exibit features observed in some experiments, most noticeably a distinct maximum in the activity curve.

Original language	English
Journal	J THEOR BIOL
Volume	218
Issue number	2
Pages (from-to)	139-147
ISSN	0022-5193
Publication status	Published - 2002

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abstract = "We study the mathematical solutions to the kinetic equations arising from various simple ligand-reactor models. Focusing on the prediction of the various models for the activity vs. concentration curve, we find that solutions to the kinetic equations arising from the so-called dimer model exibit features observed in some experiments, most noticeably a distinct maximum in the activity curve.",

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AB - We study the mathematical solutions to the kinetic equations arising from various simple ligand-reactor models. Focusing on the prediction of the various models for the activity vs. concentration curve, we find that solutions to the kinetic equations arising from the so-called dimer model exibit features observed in some experiments, most noticeably a distinct maximum in the activity curve.

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