Considerations when Measuring Biocatalyst Performance

Mafalda Dias Gomes, John M. Woodley

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Abstract

As biocatalysis matures, it becomes increasingly important to establish methods with which to measure biocatalyst performance. Such measurements are important to assess immobilization strategies, different operating modes, and reactor configurations, aside from comparing protein engineered variants and benchmarking against economic targets. While conventional measurement techniques focus on a single performance metric (such as the total turnover number), here, it is argued that three metrics (achievable product concentration, productivity, and enzyme stability) are required for an accurate assessment of scalability.
Original languageEnglish
Article number3573
JournalMolecules
Volume24
Issue number19
Number of pages11
ISSN1420-3049
DOIs
Publication statusPublished - 2019

Keywords

  • Biocatalysis
  • Immobilized enzymes
  • Turnover number
  • Process performance metrics
  • Enzyme kinetics
  • Enzyme stability

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