Confinement Spectroscopy: Probing Single DNA Molecules with Tapered Nanochannels

Karl Fredrik Persson; Pawel Utko; Walter Reisner; Niels Bent Larsen; Anders Kristensen

doi:10.1021/nl803030e

Confinement Spectroscopy: Probing Single DNA Molecules with Tapered Nanochannels

Karl Fredrik Persson, Pawel Utko, Walter Reisner, Niels Bent Larsen, Anders Kristensen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

We demonstrate a confinement spectroscopy technique capable of probing small conformational changes of unanchored single DNA molecules in a manner analogous to force spectroscopy, in the regime corresponding to femtonewton forces. In contrast to force spectroscopy, various structural forms of DNA can easily be probed, as indicated by experiments on linear and circular DNA. The extension of circular DNA is found to scale according to the de Gennes exponent, unlike for linear DNA.

Original language	English
Journal	Nano Letters
Volume	9
Issue number	4
Pages (from-to)	1382-1385
ISSN	1530-6984
DOIs	https://doi.org/10.1021/nl803030e
Publication status	Published - 2009

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title = "Confinement Spectroscopy: Probing Single DNA Molecules with Tapered Nanochannels",

abstract = "We demonstrate a confinement spectroscopy technique capable of probing small conformational changes of unanchored single DNA molecules in a manner analogous to force spectroscopy, in the regime corresponding to femtonewton forces. In contrast to force spectroscopy, various structural forms of DNA can easily be probed, as indicated by experiments on linear and circular DNA. The extension of circular DNA is found to scale according to the de Gennes exponent, unlike for linear DNA.",

author = "Persson, {Karl Fredrik} and Pawel Utko and Walter Reisner and Larsen, {Niels Bent} and Anders Kristensen",

year = "2009",

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journal = "Nano Letters",

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T1 - Confinement Spectroscopy: Probing Single DNA Molecules with Tapered Nanochannels

AU - Persson, Karl Fredrik

AU - Utko, Pawel

AU - Reisner, Walter

AU - Larsen, Niels Bent

AU - Kristensen, Anders

PY - 2009

Y1 - 2009

N2 - We demonstrate a confinement spectroscopy technique capable of probing small conformational changes of unanchored single DNA molecules in a manner analogous to force spectroscopy, in the regime corresponding to femtonewton forces. In contrast to force spectroscopy, various structural forms of DNA can easily be probed, as indicated by experiments on linear and circular DNA. The extension of circular DNA is found to scale according to the de Gennes exponent, unlike for linear DNA.

AB - We demonstrate a confinement spectroscopy technique capable of probing small conformational changes of unanchored single DNA molecules in a manner analogous to force spectroscopy, in the regime corresponding to femtonewton forces. In contrast to force spectroscopy, various structural forms of DNA can easily be probed, as indicated by experiments on linear and circular DNA. The extension of circular DNA is found to scale according to the de Gennes exponent, unlike for linear DNA.

U2 - 10.1021/nl803030e

DO - 10.1021/nl803030e

M3 - Journal article

SN - 1530-6984

VL - 9

SP - 1382

EP - 1385

JO - Nano Letters

JF - Nano Letters

IS - 4

ER -

Confinement Spectroscopy: Probing Single DNA Molecules with Tapered Nanochannels

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