Confinement Spectroscopy: Probing Single DNA Molecules with Tapered Nanochannels

Karl Fredrik Persson, Pawel Utko, Walter Reisner, Niels Bent Larsen, Anders Kristensen

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    Abstract

    We demonstrate a confinement spectroscopy technique capable of probing small conformational changes of unanchored single DNA molecules in a manner analogous to force spectroscopy, in the regime corresponding to femtonewton forces. In contrast to force spectroscopy, various structural forms of DNA can easily be probed, as indicated by experiments on linear and circular DNA. The extension of circular DNA is found to scale according to the de Gennes exponent, unlike for linear DNA.
    Original languageEnglish
    JournalNano Letters
    Volume9
    Issue number4
    Pages (from-to)1382-1385
    ISSN1530-6984
    DOIs
    Publication statusPublished - 2009

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