Conductive vancomycin-loaded mesoporous silica polypyrrole-based scaffolds for bone regeneration

Nazanin Zanjanizadeh Ezazi, Mohammad-Ali Shahbazi, Yuri V. Shatalin, Eloy Nadal, Ermei Mäkilä, Jarno Salonen, Marianna Kemell, Alexandra Correia, Jouni Hirvonen, Hélder A. Santos*

*Corresponding author for this work

    Research output: Contribution to journalJournal articleResearchpeer-review

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    Abstract

    Bone tissue engineering is considered an alternative approach for conventional strategies available to treat bone defects. In this study, we have developed bone scaffolds composed of hydroxyapaptite (HAp), gelatin and mesoporous silica, all recognized as promising materials in bone tissue engineering due to favorable biocompatibility, osteoconductivity and drug delivery potential, respectively. These materials were coupled with conductive polypyrrole (PPy) polymer to create a novel bone scaffold for regenerative medicine. Conductive and non-conductive scaffolds were made by slurry casting method and loaded with a model antibiotic, vancomycin (VCM). Their properties were compared in different experiments in which scaffolds containing PPy showed good mechanical properties, higher protein adsorption and higher percentage of VCM release over a long duration of time compared to non-conductive scaffolds. Osteoblast cells were perfectly immersed into the gelatin matrix and remained viable for 14 days. Overall, new conductive composite bone scaffolds were created and the obtained results strongly verified the applicability of this conductive scaffold in drug delivery, encouraging its further development in tissue engineering applications.
    Original languageEnglish
    JournalInternational Journal of Pharmaceutics
    Volume536
    Issue number1
    Pages (from-to)241-250
    Number of pages10
    ISSN0378-5173
    DOIs
    Publication statusPublished - 2018

    Keywords

    • Bone tissue engineering
    • Conductive polymers
    • Polypyrrole
    • Drug delivery
    • Vancomycin

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