TY - JOUR
T1 - Conductive vancomycin-loaded mesoporous silica polypyrrole-based scaffolds for bone regeneration
AU - Zanjanizadeh Ezazi, Nazanin
AU - Shahbazi, Mohammad-Ali
AU - Shatalin, Yuri V.
AU - Nadal, Eloy
AU - Mäkilä, Ermei
AU - Salonen, Jarno
AU - Kemell, Marianna
AU - Correia, Alexandra
AU - Hirvonen, Jouni
AU - Santos, Hélder A.
PY - 2018
Y1 - 2018
N2 - Bone tissue engineering is considered an alternative approach for conventional strategies available to treat bone defects. In this study, we have developed bone scaffolds composed of hydroxyapaptite (HAp), gelatin and mesoporous silica, all recognized as promising materials in bone tissue engineering due to favorable biocompatibility, osteoconductivity and drug delivery potential, respectively. These materials were coupled with conductive polypyrrole (PPy) polymer to create a novel bone scaffold for regenerative medicine. Conductive and non-conductive scaffolds were made by slurry casting method and loaded with a model antibiotic, vancomycin (VCM). Their properties were compared in different experiments in which scaffolds containing PPy showed good mechanical properties, higher protein adsorption and higher percentage of VCM release over a long duration of time compared to non-conductive scaffolds. Osteoblast cells were perfectly immersed into the gelatin matrix and remained viable for 14 days. Overall, new conductive composite bone scaffolds were created and the obtained results strongly verified the applicability of this conductive scaffold in drug delivery, encouraging its further development in tissue engineering applications.
AB - Bone tissue engineering is considered an alternative approach for conventional strategies available to treat bone defects. In this study, we have developed bone scaffolds composed of hydroxyapaptite (HAp), gelatin and mesoporous silica, all recognized as promising materials in bone tissue engineering due to favorable biocompatibility, osteoconductivity and drug delivery potential, respectively. These materials were coupled with conductive polypyrrole (PPy) polymer to create a novel bone scaffold for regenerative medicine. Conductive and non-conductive scaffolds were made by slurry casting method and loaded with a model antibiotic, vancomycin (VCM). Their properties were compared in different experiments in which scaffolds containing PPy showed good mechanical properties, higher protein adsorption and higher percentage of VCM release over a long duration of time compared to non-conductive scaffolds. Osteoblast cells were perfectly immersed into the gelatin matrix and remained viable for 14 days. Overall, new conductive composite bone scaffolds were created and the obtained results strongly verified the applicability of this conductive scaffold in drug delivery, encouraging its further development in tissue engineering applications.
KW - Bone tissue engineering
KW - Conductive polymers
KW - Polypyrrole
KW - Drug delivery
KW - Vancomycin
U2 - 10.1016/j.ijpharm.2017.11.065
DO - 10.1016/j.ijpharm.2017.11.065
M3 - Journal article
C2 - 29195917
SN - 0378-5173
VL - 536
SP - 241
EP - 250
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 1
ER -