Conductive Polymer Microelectrodes for on-chip measurement of transmitter release from living cells

Simon Tylsgaard Larsen, Marco Matteucci, Rafael J. Taboryski

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

    Abstract

    In this paper, we present techniques to trap a group of neuronal cells (PC 12) close to band microelectrodes and quantitatively measure cellular transmitter release. Different trapping approaches were investigated including coating of electrodes by layers enhancing cell attachment and by pressure driven cell trapping inside closed chip devices. Conductive polymer microelectrodes were used to measure transmitter release using electrochemical methods such as cyclic voltammetry and constant potential amperometry. By measuring the oxidation current at a cyclic voltammogram, the concentration of released transmitter molecules could be estimated.
    Original languageEnglish
    Title of host publicationProceedings of Nanotech Conference and Expo 2012
    Volume2
    Publication date2012
    Pages302 - 305
    Publication statusPublished - 2012
    EventNanotech 2012: Conference & Expo - Santa Clara Convention Center, Santa Clara, United States
    Duration: 18 Jun 201221 Jun 2012
    Conference number: 15

    Conference

    ConferenceNanotech 2012
    Number15
    LocationSanta Clara Convention Center
    CountryUnited States
    CitySanta Clara
    Period18/06/201221/06/2012

    Keywords

    • Pedot
    • Conductive polymer
    • Exocytosis
    • Neurotransmitter
    • Amperometry

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