Computerized determination of 3-D connectivity density in human iliac crest bone biopsies

J.S. Thomsen, Li. Mosekilde, J. Barlach, C.H. Søgaard, Erik Mosekilde

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Combining the physical disector principle with an algorithm for automatic non-linear alignment of disector pairs we have developed a software system for direct measurement of 3D connectivity densities in iliac crest bone biopsies. The method was applied to biopsies from 14 non-selected autopsy cases: 7 men (age range 20-84 yr) and 7 women (age range 20-86 yr). The study reveals decreases in both trabecular bone mass and connectivity density with age in women.
Original languageEnglish
JournalMathematics and Computers in Simulation
Volume40
Issue number3-4
Pages (from-to)411-423
ISSN0378-4754
Publication statusPublished - 1996

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