Abstract
The present invention relates to engineered Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems and corresponding guide RNAs that target specific nucleotide sequences at certain gene loci in the human genome. Also provided are methods of targeting, editing, and/or modifying of the human genes using the engineered CRISPR systems, and compositions and cells comprising the engineered CRISPR systems.
| Original language | English |
|---|---|
| IPC | C12N 15/ 85 A I |
| Patent number | WO2023137233 |
| Filing date | 17/01/2022 |
| Country/Territory | International Bureau of the World Intellectual Property Organization (WIPO) |
| Priority date | 17/01/2022 |
| Priority number | US202263300244P |
| Publication status | Published - 20 Jul 2023 |