Abstract
| Original language | English |
|---|---|
| Journal | Regulatory Toxicology and Pharmacology |
| Volume | 64 |
| Issue number | 1 |
| Pages (from-to) | 177-185 |
| ISSN | 0273-2300 |
| DOIs | |
| Publication status | Published - 2012 |
Keywords
- Glycoalkaloid
- α-Solanine
- α-Chaconine
- GM
- Potato
- Acetylcholinesterase (AChE)
- Hamster
- Toxicity
- Compositional analyses
Cite this
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Compositional and toxicological analysis of a GM potato line with reduced α-solanine content – A 90-day feeding study in the Syrian Golden hamster. / Langkilde, Søren; Schrøder, Malene; Frank, Thomas; Shepherd, Louise V.T.; Conner, Sean; Davies, Howard V.; Meyer, Otto A.; Danier, Jürgen; Rychlik, Michael; Belknap, William R.; McCue, Kent F.; Engel, Karl-Heinz; Stewart, Derek; Knudsen, Ib; Poulsen, Morten; Poulsen, Morten.
In: Regulatory Toxicology and Pharmacology, Vol. 64, No. 1, 2012, p. 177-185.Research output: Contribution to journal › Journal article › Research › peer-review
TY - JOUR
T1 - Compositional and toxicological analysis of a GM potato line with reduced α-solanine content – A 90-day feeding study in the Syrian Golden hamster
AU - Langkilde, Søren
AU - Schrøder, Malene
AU - Frank, Thomas
AU - Shepherd, Louise V.T.
AU - Conner, Sean
AU - Davies, Howard V.
AU - Meyer, Otto A.
AU - Danier, Jürgen
AU - Rychlik, Michael
AU - Belknap, William R.
AU - McCue, Kent F.
AU - Engel, Karl-Heinz
AU - Stewart, Derek
AU - Knudsen, Ib
AU - Poulsen, Morten
AU - Poulsen, Morten
PY - 2012
Y1 - 2012
N2 - Steroidal glycoalkaloids (GAs) are toxins, produced by plants of the Solanaceae family. The potato plant (Solanum tuberosum L.) and its tubers predominantly contain the two GAs α-chaconine and α-solanine. These compounds are believed to act in synergy, and the degree of toxicity may therefore depend on their ratio in the potato. To determine the influence of α-solanine: α-chaconine ratio in potatoes on toxicity, a GM potato line (SGT 9-2) with reduced α-solanine content, and the parental control line (Desirée wild-type) having a traditional α-solanine: α-chaconine ratio were (1) studied for compositional similarity by analysing for a range of potato constituents, and (2) used in a 90-day feeding trial with the Syrian Golden hamster to study differential toxicity. The animal feeding study used diets with up to 60% freeze-dried potato powder from either line. Whilst data indicated some compositional differences between the GM line and its wildtype control these did not raise concerns related to nutritional value or safety. Results of the feeding trials showed a low number of significant differences between potato lines with different α-solanine: α-chaconine ratio but none were considered to raise safety concerns with regard to human (or animal) consumption.
AB - Steroidal glycoalkaloids (GAs) are toxins, produced by plants of the Solanaceae family. The potato plant (Solanum tuberosum L.) and its tubers predominantly contain the two GAs α-chaconine and α-solanine. These compounds are believed to act in synergy, and the degree of toxicity may therefore depend on their ratio in the potato. To determine the influence of α-solanine: α-chaconine ratio in potatoes on toxicity, a GM potato line (SGT 9-2) with reduced α-solanine content, and the parental control line (Desirée wild-type) having a traditional α-solanine: α-chaconine ratio were (1) studied for compositional similarity by analysing for a range of potato constituents, and (2) used in a 90-day feeding trial with the Syrian Golden hamster to study differential toxicity. The animal feeding study used diets with up to 60% freeze-dried potato powder from either line. Whilst data indicated some compositional differences between the GM line and its wildtype control these did not raise concerns related to nutritional value or safety. Results of the feeding trials showed a low number of significant differences between potato lines with different α-solanine: α-chaconine ratio but none were considered to raise safety concerns with regard to human (or animal) consumption.
KW - Glycoalkaloid
KW - α-Solanine
KW - α-Chaconine
KW - GM
KW - Potato
KW - Acetylcholinesterase (AChE)
KW - Hamster
KW - Toxicity
KW - Compositional analyses
U2 - 10.1016/j.yrtph.2012.06.018
DO - 10.1016/j.yrtph.2012.06.018
M3 - Journal article
VL - 64
SP - 177
EP - 185
JO - Regulatory Toxicology and Pharmacology
JF - Regulatory Toxicology and Pharmacology
SN - 0273-2300
IS - 1
ER -