Comparison of clinical and paraclinical parameters as tools for early diagnosis of classical swine fever

Louise Lohse (Invited author), Åse Uttenthal (Invited author), Jens Nielsen (Invited author)

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    Comparison of clinical and paraclinical parameters as tools for early diagnosis of classical swine fever. Louise Lohse, Åse Uttenthal, Jens Nielsen. National Veterinary Institute, Division of Virology, Lindholm, Technical University of Denmark. Introduction: In order to limit the far-reaching socio-economic as well as the animal welfare consequences of an outbreak of classical swine fever (CSF), early diagnosis is essential. However, host-virus interactions strongly influence the course of CSF disease, and the clinical feature is not clear, thus complicating the diagnostic perspective. At the National Veterinary Institute, in Denmark, we are conducting a series of animal experiments under standardized conditions in order to investigate new parameters of clinical as well as paraclinical nature that holds the potential as diagnostic tools to improve early detection of CSF. In three recent studies, weaned pigs from 6 to 11 weeks of age were inoculated with CSFV-Lithuania, CSFV-Eystrup, CSFV-Glentorf and CSFV-Romania, respectively. All pigs were closely monitored and clinical scoring (CS) as well as body temperature (BT) recording was performed on a daily basis. Blood sample collection was performed on preselected days. For a period of 3 weeks post inoculation day (PID) 0, clinical, virological, serological, and immunological parameters were compared in order to evaluate the potential of 6 different parameters for early detection of CSF. Results: Scheme (not oploaded) Conclusion: Six different parameters were investigated for their potential as indicators for early diagnosis of CSF. Together, they constitute a promising panel for detection of CSF, however, one single parameter does not by itself hold the potential as a safe indicator of CSF in the early phase of infection. In addition, the results demonstrated that it remains a particular challenge to provide a competent diagnostic tool box for low virulent strains of CSFV, e.g. CSFV-Glentorf. Acknowledgements: The authors wish to thank the EU Reference laboratory for Classical Swine Fever, TIHO, Hannover, for kindly supplying the CSFV-Romania, the CSFV-Glentorf and the CSFV-Lithuania strains to our Institute. A special thank to NRL-Romania and NRL-Lithuania for supplying the CSFV-Romania and CSFV-Lithuania strains, respectively, to the EU Reference laboratory. This study was financially supported by Directorate for Food, Fisheries and Agri Business in Denmark, grant no. 2007-776. References: [1] Mittelholzer C. et al., Vet Microbiol 74, 293-308 (2000)
    Original languageEnglish
    Publication date2010
    Publication statusPublished - 2010
    EventAnnual Meeting of NRLs for CSF 2010 - Poland
    Duration: 1 Jan 2010 → …


    ConferenceAnnual Meeting of NRLs for CSF 2010
    Period01/01/2010 → …


    • CSFV


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