Comparative solution and solid-phase glycosylations toward a disaccharide library

K. Agoston; Lars Kröger; Agnes Agoston; Gyula Dekany; J. Thiem

doi:10.1016/j.carres.2009.04.001

Comparative solution and solid-phase glycosylations toward a disaccharide library

K. Agoston, Lars Kröger, Agnes Agoston, Gyula Dekany, J. Thiem

Department of Chemistry

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

A comparative study on solution-phase and solid-phase oligosaccharide synthesis was performed. A 16-member library containing all regioisomers of Glc-Glc, Glc-Gal, Gal-Glc, and Gal-Gal disaccharides was synthesized both in solution and on solid phase. The various reaction conditions for different approaches and corresponding yields are analyzed and discussed.

Original language	English
Journal	Carbohydrate Research
Volume	344
Issue number	12
Pages (from-to)	1428-1433
ISSN	0008-6215
DOIs	https://doi.org/10.1016/j.carres.2009.04.001
Publication status	Published - 2009

Keywords

Disaccharide library
Oligosaccharide synthesis
Solid-phase chemistry

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10.1016/j.carres.2009.04.001

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title = "Comparative solution and solid-phase glycosylations toward a disaccharide library",

abstract = "A comparative study on solution-phase and solid-phase oligosaccharide synthesis was performed. A 16-member library containing all regioisomers of Glc-Glc, Glc-Gal, Gal-Glc, and Gal-Gal disaccharides was synthesized both in solution and on solid phase. The various reaction conditions for different approaches and corresponding yields are analyzed and discussed.",

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AU - Agoston, K.

AU - Kröger, Lars

AU - Agoston, Agnes

AU - Dekany, Gyula

AU - Thiem, J.

PY - 2009

Y1 - 2009

N2 - A comparative study on solution-phase and solid-phase oligosaccharide synthesis was performed. A 16-member library containing all regioisomers of Glc-Glc, Glc-Gal, Gal-Glc, and Gal-Gal disaccharides was synthesized both in solution and on solid phase. The various reaction conditions for different approaches and corresponding yields are analyzed and discussed.

AB - A comparative study on solution-phase and solid-phase oligosaccharide synthesis was performed. A 16-member library containing all regioisomers of Glc-Glc, Glc-Gal, Gal-Glc, and Gal-Gal disaccharides was synthesized both in solution and on solid phase. The various reaction conditions for different approaches and corresponding yields are analyzed and discussed.

KW - Disaccharide library

KW - Oligosaccharide synthesis

KW - Solid-phase chemistry

U2 - 10.1016/j.carres.2009.04.001

DO - 10.1016/j.carres.2009.04.001

M3 - Journal article

SN - 0008-6215

VL - 344

SP - 1428

EP - 1433

JO - Carbohydrate Research

JF - Carbohydrate Research

IS - 12

ER -

Comparative solution and solid-phase glycosylations toward a disaccharide library

Abstract

Keywords

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