Compact potentiostat for cellular electrochemical imaging with 54 parallel channels

Marco Vergani, M. Carminati, G. Ferrari, M. Sampietro, Letizia Amato, Arto Heiskanen, Maria Dimaki, Winnie Edith Svendsen, Jenny Emnéus

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review


    A novel potentiostat containing 54 current amplifiers matched to an array of custom-fabricated 5μm microelectrodes for electrochemical imaging of released neurotransmitters is presented. The board is integrated with a programmable microfluidic cell culture system and the whole assembly is thin and compact enough to be placed under the objective of a standard microscope for simultaneous optical and electrochemical monitoring. Each channel, scanned every 54μs, features 3pA current resolution over a 5kHz bandwidth, suitable for detecting single exocytotic events. The design and electrical characterization of the system are reported together with its functionality, certified by a 54-pixel electrochemical imaging of the diffusion of a 10μl droplet of a target analyte inside the cell culture chamber.
    Original languageEnglish
    Title of host publicationProceedings of IEEE Biomedical Circuits and Systems Conference
    Publication date2012
    Publication statusPublished - 2012


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