TY - GEN
T1 - Compact potentiostat for cellular electrochemical imaging with 54 parallel channels
AU - Vergani, Marco
AU - Carminati, M.
AU - Ferrari, G.
AU - Sampietro, M.
AU - Amato, Letizia
AU - Heiskanen, Arto
AU - Dimaki, Maria
AU - Svendsen, Winnie Edith
AU - Emnéus, Jenny
PY - 2012
Y1 - 2012
N2 - A novel potentiostat containing 54 current amplifiers matched to an array of custom-fabricated 5μm microelectrodes for electrochemical imaging of released neurotransmitters is presented. The board is integrated with a programmable microfluidic cell culture system and the whole assembly is thin and compact enough to be placed under the objective of a standard microscope for simultaneous optical and electrochemical monitoring. Each channel, scanned every 54μs, features 3pA current resolution over a 5kHz bandwidth, suitable for detecting single exocytotic events. The design and electrical characterization of the system are reported together with its functionality, certified by a 54-pixel electrochemical imaging of the diffusion of a 10μl droplet of a target analyte inside the cell culture chamber.
AB - A novel potentiostat containing 54 current amplifiers matched to an array of custom-fabricated 5μm microelectrodes for electrochemical imaging of released neurotransmitters is presented. The board is integrated with a programmable microfluidic cell culture system and the whole assembly is thin and compact enough to be placed under the objective of a standard microscope for simultaneous optical and electrochemical monitoring. Each channel, scanned every 54μs, features 3pA current resolution over a 5kHz bandwidth, suitable for detecting single exocytotic events. The design and electrical characterization of the system are reported together with its functionality, certified by a 54-pixel electrochemical imaging of the diffusion of a 10μl droplet of a target analyte inside the cell culture chamber.
U2 - 10.1109/BioCAS.2012.6418401
DO - 10.1109/BioCAS.2012.6418401
M3 - Article in proceedings
BT - Proceedings of IEEE Biomedical Circuits and Systems Conference
ER -