Common genetic variants are associated with lower serum 25-hydroxyvitamin D concentrations across the year among children at northern latitudes

Rikke A. Petersen, Lesli Hingstrup Larsen, Camilla T. Damsgaard, Louise B. Sørensen, Mads F. Hjorth, Rikke Andersen, Inge Tetens, Henrik Krarup, Christian Ritz, Arne Astrup, Kim F. Michaelsen, Christian Mølgaard

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Abstract

In a longitudinal study including 642 healthy 8-11-year-old Danish children, we investigated associations between vitamin D dependent SNP and serum 25-hydroxyvitamin D (25(OH)D) concentrations across a school year (August-June). Serum 25(OH)D was measured three times for every child, which approximated measurements in three seasons (autumn, winter, spring). Dietary and supplement intake, physical activity, BMI and parathyroid hormone were likewise measured at each time point. In all, eleven SNP in four vitamin D-related genes: Cytochrome P450 subfamily IIR1 (CYP2R1); 7-dehydrocholesterol reductase/nicotinamide adenine dinucleotide synthetase-1(DHCR7/NADSYN1); group-specific complement (GC); and vitamin D receptor were genotyped. We found minor alleles of CYP2R1 rs10500804, and of GC rs4588 and rs7041 to be associated with lower serum 25(OH)D concentrations across the three seasons (all P
Original languageEnglish
JournalBritish Journal of Nutrition
Volume117
Issue number6
Pages (from-to)829-838
Number of pages10
ISSN0007-1145
DOIs
Publication statusPublished - 2017

Keywords

  • Journal Article
  • CYP2R1 cytochrome P450 subfamily IIR1
  • GC group-specific complement
  • 25(OH)D 25-hydroxyvitamin D
  • DBP vitamin D-binding protein
  • PTH parathyroid hormone
  • Children
  • Genetic variations
  • Northern latitudes
  • Vitamin D

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