Combining radiotherapy with immunotherapy: the past, the present and the future

Evert J. Van Limbergen, Dirk K. De Ruysscher, Veronica Olivo Pimentel, Damiënne Marcus, Maaike Berbee, Ann Hoeben, Nicolle Rekers, Jan Theys, Ala Yaromina, Ludwig J. Dubois, Philippe Lambin

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    Abstract

    The advent of immunotherapy is currently revolutionizing the field of oncology, where different drugs are used to stimulate different steps in a failing cancer immune response chain. This review gives a basic overview of the immune response against cancer, as well as the historical and current evidence on the interaction of radiotherapy with the immune system and the different forms of immunotherapy. Furthermore the review elaborates on the many open questions on how to exploit this interaction to the full extent in clinical practice.
    Original languageEnglish
    Article number20170157
    JournalBritish Journal of Radiology
    Volume90
    Issue number1076
    ISSN0007-1285
    DOIs
    Publication statusPublished - 2017

    Bibliographical note

    This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 Unported License http://creativecommons.org/licenses/by-nc/4.0/, which permits unrestricted non-commercial reuse, provided the original author and source are credited.

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