Combinatorial Chemistry of Piperidine Based Carbohydrate Mimics

Elisabeth Vang Byrgesen; John Nielsen; Marianne Willart; Mikael Bols

doi:10.1016/S0040-4039(97)01249-5

Combinatorial Chemistry of Piperidine Based Carbohydrate Mimics

Elisabeth Vang Byrgesen
, John Nielsen
, Marianne Willart
, Mikael Bols

Aarhus University

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Piperidine carboxylic acids and 4-hydroxypiperidine-3-carboxylic acid, the latter obtained from bakers yeast reduction of the corresponding piperidone, were coupled in solid-phase synthesis to form simplified oligosaccharide analogues. A split-and-mix synthesis approach was used to create small combinatorial libraries which were characterised by LC-MS and screened as inhibitors of glycosidases. (C) 1997 Elsevier Science Ltd.

Original language	English
Journal	Tetrahedron Letters
Volume	38
Issue number	32
Pages (from-to)	5697-5700
ISSN	0040-4039
DOIs	https://doi.org/10.1016/S0040-4039(97)01249-5
Publication status	Published - 1997

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title = "Combinatorial Chemistry of Piperidine Based Carbohydrate Mimics",

abstract = "Piperidine carboxylic acids and 4-hydroxypiperidine-3-carboxylic acid, the latter obtained from bakers yeast reduction of the corresponding piperidone, were coupled in solid-phase synthesis to form simplified oligosaccharide analogues. A split-and-mix synthesis approach was used to create small combinatorial libraries which were characterised by LC-MS and screened as inhibitors of glycosidases. (C) 1997 Elsevier Science Ltd. ",

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doi = "10.1016/S0040-4039(97)01249-5",

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T1 - Combinatorial Chemistry of Piperidine Based Carbohydrate Mimics

AU - Byrgesen, Elisabeth Vang

AU - Nielsen, John

AU - Willart, Marianne

AU - Bols, Mikael

PY - 1997

Y1 - 1997

N2 - Piperidine carboxylic acids and 4-hydroxypiperidine-3-carboxylic acid, the latter obtained from bakers yeast reduction of the corresponding piperidone, were coupled in solid-phase synthesis to form simplified oligosaccharide analogues. A split-and-mix synthesis approach was used to create small combinatorial libraries which were characterised by LC-MS and screened as inhibitors of glycosidases. (C) 1997 Elsevier Science Ltd.

AB - Piperidine carboxylic acids and 4-hydroxypiperidine-3-carboxylic acid, the latter obtained from bakers yeast reduction of the corresponding piperidone, were coupled in solid-phase synthesis to form simplified oligosaccharide analogues. A split-and-mix synthesis approach was used to create small combinatorial libraries which were characterised by LC-MS and screened as inhibitors of glycosidases. (C) 1997 Elsevier Science Ltd.

U2 - 10.1016/S0040-4039(97)01249-5

DO - 10.1016/S0040-4039(97)01249-5

M3 - Journal article

SN - 0040-4039

VL - 38

SP - 5697

EP - 5700

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 32

ER -

Combinatorial Chemistry of Piperidine Based Carbohydrate Mimics

Abstract

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