Combinatorial Chemistry of Piperidine Based Carbohydrate Mimics

Elisabeth Vang Byrgesen, John Nielsen, Marianne Willart, Mikael Bols

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Piperidine carboxylic acids and 4-hydroxypiperidine-3-carboxylic acid, the latter obtained from bakers yeast reduction of the corresponding piperidone, were coupled in solid-phase synthesis to form simplified oligosaccharide analogues. A split-and-mix synthesis approach was used to create small combinatorial libraries which were characterised by LC-MS and screened as inhibitors of glycosidases. (C) 1997 Elsevier Science Ltd.
    Original languageEnglish
    JournalTetrahedron Letters
    Volume38
    Issue number32
    Pages (from-to)5697-5700
    ISSN0040-4039
    DOIs
    Publication statusPublished - 1997

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