Combination effects of pesticides on birth weight and metabolic programming in rat offspring

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Abstract

Risk assessment of pesticides is generally based on the no observed adverse effect levels (NOAELs) for single compounds. However, humans are typically exposed to a mixture of several pesticides. The objectives of the project were to investigate whether a mixture of environmentally relevant pesticides cause decreased birth weights at dose levels below NOAELs for the individual pesticides in rats, to evaluate whether the mixture effect is best predicted by the independent action or the dose-addition model, to investigate the influences of developmental pesticide exposure on metabolic programming of the offspring using biomarkers for obesity and type 2 diabetes, and to give input for regulatory considerations.
Original languageEnglish
Place of PublicationKøbenhavn Ø
PublisherEnvironmental Protection Agency
Number of pages78
ISBN (Electronic)978-87-93529-72-4
Publication statusPublished - 2018

Cite this

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title = "Combination effects of pesticides on birth weight and metabolic programming in rat offspring",
abstract = "Risk assessment of pesticides is generally based on the no observed adverse effect levels (NOAELs) for single compounds. However, humans are typically exposed to a mixture of several pesticides. The objectives of the project were to investigate whether a mixture of environmentally relevant pesticides cause decreased birth weights at dose levels below NOAELs for the individual pesticides in rats, to evaluate whether the mixture effect is best predicted by the independent action or the dose-addition model, to investigate the influences of developmental pesticide exposure on metabolic programming of the offspring using biomarkers for obesity and type 2 diabetes, and to give input for regulatory considerations.",
author = "Ulla Hass and Sofie Christiansen and Julie Boberg and Petersen, {Marta Axelstad} and Egebjerg, {Karen Mandrup} and Vinggaard, {Anne Marie} and Camilla Taxvig and Terje Svingen and Louise Ramh{\o}j and Martin Scholze",
year = "2018",
language = "English",
publisher = "Environmental Protection Agency",

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T1 - Combination effects of pesticides on birth weight and metabolic programming in rat offspring

AU - Hass, Ulla

AU - Christiansen, Sofie

AU - Boberg, Julie

AU - Petersen, Marta Axelstad

AU - Egebjerg, Karen Mandrup

AU - Vinggaard, Anne Marie

AU - Taxvig, Camilla

AU - Svingen, Terje

AU - Ramhøj, Louise

AU - Scholze, Martin

PY - 2018

Y1 - 2018

N2 - Risk assessment of pesticides is generally based on the no observed adverse effect levels (NOAELs) for single compounds. However, humans are typically exposed to a mixture of several pesticides. The objectives of the project were to investigate whether a mixture of environmentally relevant pesticides cause decreased birth weights at dose levels below NOAELs for the individual pesticides in rats, to evaluate whether the mixture effect is best predicted by the independent action or the dose-addition model, to investigate the influences of developmental pesticide exposure on metabolic programming of the offspring using biomarkers for obesity and type 2 diabetes, and to give input for regulatory considerations.

AB - Risk assessment of pesticides is generally based on the no observed adverse effect levels (NOAELs) for single compounds. However, humans are typically exposed to a mixture of several pesticides. The objectives of the project were to investigate whether a mixture of environmentally relevant pesticides cause decreased birth weights at dose levels below NOAELs for the individual pesticides in rats, to evaluate whether the mixture effect is best predicted by the independent action or the dose-addition model, to investigate the influences of developmental pesticide exposure on metabolic programming of the offspring using biomarkers for obesity and type 2 diabetes, and to give input for regulatory considerations.

M3 - Report

BT - Combination effects of pesticides on birth weight and metabolic programming in rat offspring

PB - Environmental Protection Agency

CY - København Ø

ER -