TY - RPRT
T1 - Combination effects of pesticides on birth weight and metabolic programming in rat offspring
AU - Hass, Ulla
AU - Christiansen, Sofie
AU - Boberg, Julie
AU - Petersen, Marta Axelstad
AU - Egebjerg, Karen Mandrup
AU - Vinggaard, Anne Marie
AU - Taxvig, Camilla
AU - Svingen, Terje
AU - Ramhøj, Louise
AU - Scholze, Martin
PY - 2018
Y1 - 2018
N2 - Risk assessment of pesticides is generally based on the no observed adverse effect levels (NOAELs) for single compounds. However, humans are typically exposed to a mixture of several pesticides. The objectives of the project were to investigate whether a mixture of environmentally relevant pesticides cause decreased birth weights at dose levels below NOAELs for the individual pesticides in rats, to evaluate whether the mixture effect is best predicted by the independent action or the dose-addition model, to investigate the influences of developmental pesticide exposure on metabolic programming of the offspring using biomarkers for obesity and type 2 diabetes, and to give input for regulatory considerations.
AB - Risk assessment of pesticides is generally based on the no observed adverse effect levels (NOAELs) for single compounds. However, humans are typically exposed to a mixture of several pesticides. The objectives of the project were to investigate whether a mixture of environmentally relevant pesticides cause decreased birth weights at dose levels below NOAELs for the individual pesticides in rats, to evaluate whether the mixture effect is best predicted by the independent action or the dose-addition model, to investigate the influences of developmental pesticide exposure on metabolic programming of the offspring using biomarkers for obesity and type 2 diabetes, and to give input for regulatory considerations.
M3 - Report
BT - Combination effects of pesticides on birth weight and metabolic programming in rat offspring
PB - Environmental Protection Agency
CY - København Ø
ER -
