In conclusion, SN38-and Oxp-resistance in CRC cells is associated with SLC1A1 and -3 dysregulation. As these transporters have not previously been implicated in SN38 or Oxp resistance and are generally restricted to the CNS, they are potential novel biomarkers for resistance and interesting candidates for therapeutic targeting.
|Journal||F A S E B Journal|
|Publication status||Published - 2013|
|Event||Joint Annual Meeting of the ASPET/BPS at Experimental Biology - Boston, United States|
Duration: 20 Apr 2013 → 24 Apr 2013
|Conference||Joint Annual Meeting of the ASPET/BPS at Experimental Biology|
|Period||20/04/2013 → 24/04/2013|