Color test for selective detection of secondary amines on resin and in solution.

Ulrik Boas, Sahar Mirsharghi

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Resins for solid-phase synthesis give orange to red-brown resin beads selectively when secondary amines are present on the resin when treated with a solution of acetaldehyde and an Fmoc-amino acid in NMP. The method shows good specificity and gives colorless beads when exposed to a variety of other functional groups. Furthermore, the acetaldehyde/Fmoc amino acid method can be used as a selective colorimetric test for secondary amines in solution.
Original languageEnglish
JournalORGANIC LETTERS
Volume16
Issue number22
Pages (from-to)5918-5921
Number of pages4
ISSN1523-7060
DOIs
Publication statusPublished - 2014

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