Collective vibrational modes in biological molecules investigated by terahertz time-domain spectroscopy

M. Walther, P. Plochocka, B. Fischer, H. Helm, Peter Uhd Jepsen

Research output: Contribution to journalConference articleResearchpeer-review

Abstract

We present well-resolved absorption spectra of biological molecules in the far-IR (FIR) spectral region recorded by terahertz time-domain spectroscopy (THzTDS). As an illustrative example we discuss the absorption spectra of benzoic acid, its monosubstitutes salicylic acid (2-hydroxy-benzoic acid), 3- and 4-hydroxybenzoic acid, and aspirin (acetylsalicylic acid) in the spectral region between 18 and 150 cm(-1). The spectra exhibit distinct features originating from low-frequency vibrational modes caused by intra- or intermolecular collective motion and lattice modes. Due to the collective origin of the observed modes the absorption spectra are highly sensitive to the overall structure and configuration of the molecules, as well as their environment. The THz-TDS procedure can provide a direct fingerprint of the molecular structure or conformational state of a compound. (C) 2002 Wiley Periodicals, Inc.
Original languageEnglish
JournalBiopolymers
Volume67
Issue number4-5
Pages (from-to)310-313
Number of pages4
ISSN0006-3525
DOIs
Publication statusPublished - 2002
Externally publishedYes
EventEuropean Conference on the Spectroscopy of Biological Molecules - Prague, Czech Republic
Duration: 8 Sep 200113 Sep 2001
Conference number: 9

Conference

ConferenceEuropean Conference on the Spectroscopy of Biological Molecules
Number9
Country/TerritoryCzech Republic
CityPrague
Period08/09/200113/09/2001

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