Colistin Resistance Mediated by mcr-1 in ESBL-Producing, Multidrug Resistant Salmonella Infantis in Broiler Chicken Industry, Italy (2016-2017)

Virginia Carfora, Patricia Alba, Pimlapas Leekitcharoenphon, Daniele Ballaro, Gessica Cordaro, Paola Di Matteo, Valentina Donati, Angela Ianzano, Manuela Iurescia, Fiorentino Stravino, Tania Tagliaferri, Antonio Battisti*, Alessia Franco

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

216 Downloads (Pure)

Abstract

Colistin-resistance mediated by mobilisable and plasmid-borne mcr genes has emerged worldwide, threatening the efficacy of colistin, a last resort antibiotic increasingly used for treating human invasive infections by multidrug-resistant or extensively drug-resistant Enterobacteriaceae. In this study, we report the first evidence of mcr-1-mediated colistin resistance in four multidrug resistant (MDR) out of 324 Salmonella infantis from the Italian antimicrobial resistance (AMR) monitoring (2001-2017) in broilers and broiler meat. Two were also Extended Spectrum Beta-Lactamases (ESBL)-producing isolates. Characterization by whole genome sequencing (WGS), located mcr-1.1 on an incX4 plasmid. Phylogenetic analysis of these isolates with selected Italian S. Infantis previously isolated from animals, meat and human clinical cases with unknown epidemiological relationship, demonstrated that ESBL-producing, mcr-1-positive isolates belonged to the emerging pESI-like-positive-ESBL-producing clone described in Italy in 2015.
Original languageEnglish
Article number1880
JournalFrontiers in Microbiology
Volume9
Number of pages6
ISSN1664-302X
DOIs
Publication statusPublished - 2018

Keywords

  • colistin resistance
  • mcr genes
  • ESBL (Extended Spectrum Beta-Lactamases)
  • plasmids
  • whole genome sequencing
  • Salmonella Infantis
  • broilers
  • broiler meat
  • Microbiology
  • Microbiology (medical)
  • Broiler meat
  • Broilers
  • Colistin resistance
  • Mcr genes
  • Plasmids
  • Whole genome sequencing

Fingerprint

Dive into the research topics of 'Colistin Resistance Mediated by mcr-1 in ESBL-Producing, Multidrug Resistant Salmonella Infantis in Broiler Chicken Industry, Italy (2016-2017)'. Together they form a unique fingerprint.

Cite this