A theory is presented for coherent topological phenomena in protein dynamics with implications for protein folding and stability. We discuss the relationship to the writhing number used in knot diagrams of DNA. The winding state defines a long-range order along the backbone of a protein with long-range excitations, `wring' modes, that play an important role in protein denaturation and stability. Energy can be pumped into these excitations, either thermally or by an external force.
|Journal||Folding and Design|
|Publication status||Published - 1997|
|Event||Distance-Based Approaches to Protein Structure
Determination III - Copenhagen|
Duration: 1 Jan 1996 → …
|Conference||Distance-Based Approaches to Protein Structure Determination III|
|Period||01/01/1996 → …|