Coherent topological phenomena in protein folding

Henrik Bohr, Søren Brunak, Jakob Bohr

Research output: Contribution to journalJournal articleResearchpeer-review


A theory is presented for coherent topological phenomena in protein dynamics with implications for protein folding and stability. We discuss the relationship to the writhing number used in knot diagrams of DNA. The winding state defines a long-range order along the backbone of a protein with long-range excitations, `wring' modes, that play an important role in protein denaturation and stability. Energy can be pumped into these excitations, either thermally or by an external force.
Original languageEnglish
JournalFolding and Design
Pages (from-to)S15-S18
Publication statusPublished - 1997
EventDistance-Based Approaches to Protein Structure Determination III - Copenhagen
Duration: 1 Jan 1996 → …


ConferenceDistance-Based Approaches to Protein Structure Determination III
Period01/01/1996 → …


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