Co-localization of carbapenem (blaOXA-162) and colistin (mcr-1) resistance genes on a transferable IncHI2 plasmid in Escherichia coli of chicken origin

Valeria Bortolaia; Troels Ronco; Luminita Romascu; Isabela Nicorescu; Nicoleta M. Milita; Angela M. Vaduva; Pimlapas Leekitcharoenphon; Jette S. Kjeldgaard; Inge M. Hansen; Christina A. Svendsen; Hanne Mordhorst; Beatriz Guerra; Pierre-Alexandre Beloeil; Maria Hoffmann; René S. Hendriksen

doi:10.1093/jac/dkab285

Co-localization of carbapenem (bla_OXA-162) and colistin (mcr-1) resistance genes on a transferable IncHI2 plasmid in Escherichia coli of chicken origin

Valeria Bortolaia
, Troels Ronco^*
, Luminita Romascu
, Isabela Nicorescu
, Nicoleta M. Milita
, Angela M. Vaduva
, Pimlapas Leekitcharoenphon
, Jette S. Kjeldgaard
, Inge M. Hansen
, Christina A. Svendsen
, Hanne Mordhorst
, Beatriz Guerra
, Pierre-Alexandre Beloeil
, Maria Hoffmann
, René S. Hendriksen

^*Corresponding author for this work

European Food Safety Authority
University of Bucharest
United States Food and Drug Administration

Research output: Contribution to journal › Letter › peer-review

140 Downloads (Orbit)

Abstract

Carbapenems are critically important antimicrobials for the treatment of clinical infections caused by MDR Enterobacteriaceae, with colistin reserved for those cases in which even carbapenems are ineffective. Therefore, co-localization of carbapenem and colistin resistance genes on the same plasmid is worrisome and, to date, has been described only in China in an Escherichia coli from a diseased chicken (bla_NDM-4 and mcr-1 on an IncHI2/ST3 plasmid)1 and in an E. coli from a diseased pet cat (bla_NDM-5 and mcr-1 on an IncX3-X4 hybrid plasmid).2 Here, we report a novel case of co-localization of bla_OXA-162 carbapenemase and mcr-1 on a transferable IncHI2 plasmid in E. coli from a healthy broiler chicken in Europe.

Original language	English
Article number	dkab285
Journal	Journal of Antimicrobial Chemotherapy
Volume	76
Issue number	11
Pages (from-to)	3063-3065
Number of pages	3
ISSN	0305-7453
DOIs	https://doi.org/10.1093/jac/dkab285
Publication status	Published - 2021

Access to Document

10.1093/jac/dkab285Licence: CC BY-NC

FulltextFinal published version, 244 KBLicence: CC BY-NC

OpenUrl availability

Check availability in DTU Findit

Cite this

Bortolaia, V., Ronco, T., Romascu, L., Nicorescu, I., Milita, N. M., Vaduva, A. M., Leekitcharoenphon, P., Kjeldgaard, J. S., Hansen, I. M., Svendsen, C. A., Mordhorst, H., Guerra, B., Beloeil, P.-A., Hoffmann, M., & Hendriksen, R. S. (2021). Co-localization of carbapenem (bla_OXA-162) and colistin (mcr-1) resistance genes on a transferable IncHI2 plasmid in Escherichia coli of chicken origin. Journal of Antimicrobial Chemotherapy, 76(11), 3063-3065. Article dkab285. https://doi.org/10.1093/jac/dkab285

@article{6c3281a3e100464cbfa132958d690cf9,

title = "Co-localization of carbapenem (blaOXA-162) and colistin (mcr-1) resistance genes on a transferable IncHI2 plasmid in Escherichia coli of chicken origin",

abstract = "Carbapenems are critically important antimicrobials for the treatment of clinical infections caused by MDR Enterobacteriaceae, with colistin reserved for those cases in which even carbapenems are ineffective. Therefore, co-localization of carbapenem and colistin resistance genes on the same plasmid is worrisome and, to date, has been described only in China in an Escherichia coli from a diseased chicken (blaNDM-4 and mcr-1 on an IncHI2/ST3 plasmid)1 and in an E. coli from a diseased pet cat (blaNDM-5 and mcr-1 on an IncX3-X4 hybrid plasmid).2 Here, we report a novel case of co-localization of blaOXA-162 carbapenemase and mcr-1 on a transferable IncHI2 plasmid in E. coli from a healthy broiler chicken in Europe.",

author = "Valeria Bortolaia and Troels Ronco and Luminita Romascu and Isabela Nicorescu and Milita, \{Nicoleta M.\} and Vaduva, \{Angela M.\} and Pimlapas Leekitcharoenphon and Kjeldgaard, \{Jette S.\} and Hansen, \{Inge M.\} and Svendsen, \{Christina A.\} and Hanne Mordhorst and Beatriz Guerra and Pierre-Alexandre Beloeil and Maria Hoffmann and Hendriksen, \{Ren{\'e} S.\}",

year = "2021",

doi = "10.1093/jac/dkab285",

language = "English",

volume = "76",

pages = "3063--3065",

journal = "Journal of Antimicrobial Chemotherapy",

issn = "0305-7453",

publisher = "Oxford University Press",

number = "11",

}

Bortolaia, V, Ronco, T, Romascu, L, Nicorescu, I, Milita, NM, Vaduva, AM, Leekitcharoenphon, P , Kjeldgaard, JS, Hansen, IM, Svendsen, CA, Mordhorst, H, Guerra, B, Beloeil, P-A, Hoffmann, M & Hendriksen, RS 2021, 'Co-localization of carbapenem (bla_OXA-162) and colistin (mcr-1) resistance genes on a transferable IncHI2 plasmid in Escherichia coli of chicken origin', Journal of Antimicrobial Chemotherapy, vol. 76, no. 11, dkab285, pp. 3063-3065. https://doi.org/10.1093/jac/dkab285

Co-localization of carbapenem (bla_OXA-162) and colistin (mcr-1) resistance genes on a transferable IncHI2 plasmid in Escherichia coli of chicken origin. / Bortolaia, Valeria; Ronco, Troels; Romascu, Luminita et al.
In: Journal of Antimicrobial Chemotherapy, Vol. 76, No. 11, dkab285, 2021, p. 3063-3065.

Research output: Contribution to journal › Letter › peer-review

TY - JOUR

T1 - Co-localization of carbapenem (blaOXA-162) and colistin (mcr-1) resistance genes on a transferable IncHI2 plasmid in Escherichia coli of chicken origin

AU - Bortolaia, Valeria

AU - Ronco, Troels

AU - Romascu, Luminita

AU - Nicorescu, Isabela

AU - Milita, Nicoleta M.

AU - Vaduva, Angela M.

AU - Leekitcharoenphon, Pimlapas

AU - Kjeldgaard, Jette S.

AU - Hansen, Inge M.

AU - Svendsen, Christina A.

AU - Mordhorst, Hanne

AU - Guerra, Beatriz

AU - Beloeil, Pierre-Alexandre

AU - Hoffmann, Maria

AU - Hendriksen, René S.

PY - 2021

Y1 - 2021

N2 - Carbapenems are critically important antimicrobials for the treatment of clinical infections caused by MDR Enterobacteriaceae, with colistin reserved for those cases in which even carbapenems are ineffective. Therefore, co-localization of carbapenem and colistin resistance genes on the same plasmid is worrisome and, to date, has been described only in China in an Escherichia coli from a diseased chicken (blaNDM-4 and mcr-1 on an IncHI2/ST3 plasmid)1 and in an E. coli from a diseased pet cat (blaNDM-5 and mcr-1 on an IncX3-X4 hybrid plasmid).2 Here, we report a novel case of co-localization of blaOXA-162 carbapenemase and mcr-1 on a transferable IncHI2 plasmid in E. coli from a healthy broiler chicken in Europe.

AB - Carbapenems are critically important antimicrobials for the treatment of clinical infections caused by MDR Enterobacteriaceae, with colistin reserved for those cases in which even carbapenems are ineffective. Therefore, co-localization of carbapenem and colistin resistance genes on the same plasmid is worrisome and, to date, has been described only in China in an Escherichia coli from a diseased chicken (blaNDM-4 and mcr-1 on an IncHI2/ST3 plasmid)1 and in an E. coli from a diseased pet cat (blaNDM-5 and mcr-1 on an IncX3-X4 hybrid plasmid).2 Here, we report a novel case of co-localization of blaOXA-162 carbapenemase and mcr-1 on a transferable IncHI2 plasmid in E. coli from a healthy broiler chicken in Europe.

U2 - 10.1093/jac/dkab285

DO - 10.1093/jac/dkab285

M3 - Letter

C2 - 34392339

SN - 0305-7453

VL - 76

SP - 3063

EP - 3065

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 11

M1 - dkab285

ER -