Co-localization of carbapenem (blaOXA-162) and colistin (mcr-1) resistance genes on a transferable IncHI2 plasmid in Escherichia coli of chicken origin

Valeria Bortolaia, Troels Ronco*, Luminita Romascu, Isabela Nicorescu, Nicoleta M. Milita, Angela M. Vaduva, Pimlapas Leekitcharoenphon, Jette S. Kjeldgaard, Inge M. Hansen, Christina A. Svendsen, Hanne Mordhorst, Beatriz Guerra, Pierre-Alexandre Beloeil, Maria Hoffmann, René S. Hendriksen

*Corresponding author for this work

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Abstract

Carbapenems are critically important antimicrobials for the treatment of clinical infections caused by MDR Enterobacteriaceae, with colistin reserved for those cases in which even carbapenems are ineffective. Therefore, co-localization of carbapenem and colistin resistance genes on the same plasmid is worrisome and, to date, has been described only in China in an Escherichia coli from a diseased chicken (blaNDM-4 and mcr-1 on an IncHI2/ST3 plasmid)1 and in an E. coli from a diseased pet cat (blaNDM-5 and mcr-1 on an IncX3-X4 hybrid plasmid).2 Here, we report a novel case of co-localization of blaOXA-162 carbapenemase and mcr-1 on a transferable IncHI2 plasmid in E. coli from a healthy broiler chicken in Europe.
Original languageEnglish
Article numberdkab285
JournalJournal of Antimicrobial Chemotherapy
Volume76
Issue number11
Pages (from-to)3063-3065
Number of pages3
ISSN0305-7453
DOIs
Publication statusPublished - 2021

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