Co-localization of carbapenem (blaOXA-162) and colistin (mcr-1) resistance genes on a transferable IncHI2 plasmid in Escherichia coli of chicken origin

Valeria Bortolaia; Troels Ronco; Luminita Romascu; Isabela Nicorescu; Nicoleta M. Milita; Angela M. Vaduva; Pimlapas Leekitcharoenphon; Jette S. Kjeldgaard; Inge M. Hansen; Christina A. Svendsen; Hanne Mordhorst; Beatriz Guerra; Pierre-Alexandre Beloeil; Maria Hoffmann; René S. Hendriksen

doi:10.1093/jac/dkab285

Co-localization of carbapenem (bla_OXA-162) and colistin (mcr-1) resistance genes on a transferable IncHI2 plasmid in Escherichia coli of chicken origin

Valeria Bortolaia, Troels Ronco^*, Luminita Romascu, Isabela Nicorescu, Nicoleta M. Milita, Angela M. Vaduva, Pimlapas Leekitcharoenphon, Jette S. Kjeldgaard, Inge M. Hansen, Christina A. Svendsen, Hanne Mordhorst, Beatriz Guerra, Pierre-Alexandre Beloeil, Maria Hoffmann, René S. Hendriksen

^*Corresponding author for this work

Research output: Contribution to journal › Letter › peer-review

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Abstract

Carbapenems are critically important antimicrobials for the treatment of clinical infections caused by MDR Enterobacteriaceae, with colistin reserved for those cases in which even carbapenems are ineffective. Therefore, co-localization of carbapenem and colistin resistance genes on the same plasmid is worrisome and, to date, has been described only in China in an Escherichia coli from a diseased chicken (bla_NDM-4 and mcr-1 on an IncHI2/ST3 plasmid)1 and in an E. coli from a diseased pet cat (bla_NDM-5 and mcr-1 on an IncX3-X4 hybrid plasmid).2 Here, we report a novel case of co-localization of bla_OXA-162 carbapenemase and mcr-1 on a transferable IncHI2 plasmid in E. coli from a healthy broiler chicken in Europe.

Original language	English
Article number	dkab285
Journal	Journal of Antimicrobial Chemotherapy
Volume	76
Issue number	11
Pages (from-to)	3063-3065
Number of pages	3
ISSN	0305-7453
DOIs	https://doi.org/10.1093/jac/dkab285
Publication status	Published - 2021

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Bortolaia, V., Ronco, T., Romascu, L., Nicorescu, I., Milita, N. M., Vaduva, A. M., Leekitcharoenphon, P., Kjeldgaard, J. S., Hansen, I. M., Svendsen, C. A., Mordhorst, H., Guerra, B., Beloeil, P.-A., Hoffmann, M., & Hendriksen, R. S. (2021). Co-localization of carbapenem (bla_OXA-162) and colistin (mcr-1) resistance genes on a transferable IncHI2 plasmid in Escherichia coli of chicken origin. Journal of Antimicrobial Chemotherapy, 76(11), 3063-3065. Article dkab285. https://doi.org/10.1093/jac/dkab285

@article{6c3281a3e100464cbfa132958d690cf9,

title = "Co-localization of carbapenem (blaOXA-162) and colistin (mcr-1) resistance genes on a transferable IncHI2 plasmid in Escherichia coli of chicken origin",

abstract = "Carbapenems are critically important antimicrobials for the treatment of clinical infections caused by MDR Enterobacteriaceae, with colistin reserved for those cases in which even carbapenems are ineffective. Therefore, co-localization of carbapenem and colistin resistance genes on the same plasmid is worrisome and, to date, has been described only in China in an Escherichia coli from a diseased chicken (blaNDM-4 and mcr-1 on an IncHI2/ST3 plasmid)1 and in an E. coli from a diseased pet cat (blaNDM-5 and mcr-1 on an IncX3-X4 hybrid plasmid).2 Here, we report a novel case of co-localization of blaOXA-162 carbapenemase and mcr-1 on a transferable IncHI2 plasmid in E. coli from a healthy broiler chicken in Europe.",

author = "Valeria Bortolaia and Troels Ronco and Luminita Romascu and Isabela Nicorescu and Milita, {Nicoleta M.} and Vaduva, {Angela M.} and Pimlapas Leekitcharoenphon and Kjeldgaard, {Jette S.} and Hansen, {Inge M.} and Svendsen, {Christina A.} and Hanne Mordhorst and Beatriz Guerra and Pierre-Alexandre Beloeil and Maria Hoffmann and Hendriksen, {Ren{\'e} S.}",

year = "2021",

doi = "10.1093/jac/dkab285",

language = "English",

volume = "76",

pages = "3063--3065",

journal = "Journal of Antimicrobial Chemotherapy",

issn = "0305-7453",

publisher = "Oxford University Press",

number = "11",

}

Bortolaia, V, Ronco, T, Romascu, L, Nicorescu, I, Milita, NM, Vaduva, AM, Leekitcharoenphon, P , Kjeldgaard, JS, Hansen, IM, Svendsen, CA, Mordhorst, H, Guerra, B, Beloeil, P-A, Hoffmann, M & Hendriksen, RS 2021, 'Co-localization of carbapenem (bla_OXA-162) and colistin (mcr-1) resistance genes on a transferable IncHI2 plasmid in Escherichia coli of chicken origin', Journal of Antimicrobial Chemotherapy, vol. 76, no. 11, dkab285, pp. 3063-3065. https://doi.org/10.1093/jac/dkab285

Co-localization of carbapenem (bla_OXA-162) and colistin (mcr-1) resistance genes on a transferable IncHI2 plasmid in Escherichia coli of chicken origin. / Bortolaia, Valeria; Ronco, Troels; Romascu, Luminita et al.
In: Journal of Antimicrobial Chemotherapy, Vol. 76, No. 11, dkab285, 2021, p. 3063-3065.

Research output: Contribution to journal › Letter › peer-review

TY - JOUR

T1 - Co-localization of carbapenem (blaOXA-162) and colistin (mcr-1) resistance genes on a transferable IncHI2 plasmid in Escherichia coli of chicken origin

AU - Bortolaia, Valeria

AU - Ronco, Troels

AU - Romascu, Luminita

AU - Nicorescu, Isabela

AU - Milita, Nicoleta M.

AU - Vaduva, Angela M.

AU - Leekitcharoenphon, Pimlapas

AU - Kjeldgaard, Jette S.

AU - Hansen, Inge M.

AU - Svendsen, Christina A.

AU - Mordhorst, Hanne

AU - Guerra, Beatriz

AU - Beloeil, Pierre-Alexandre

AU - Hoffmann, Maria

AU - Hendriksen, René S.

PY - 2021

Y1 - 2021

N2 - Carbapenems are critically important antimicrobials for the treatment of clinical infections caused by MDR Enterobacteriaceae, with colistin reserved for those cases in which even carbapenems are ineffective. Therefore, co-localization of carbapenem and colistin resistance genes on the same plasmid is worrisome and, to date, has been described only in China in an Escherichia coli from a diseased chicken (blaNDM-4 and mcr-1 on an IncHI2/ST3 plasmid)1 and in an E. coli from a diseased pet cat (blaNDM-5 and mcr-1 on an IncX3-X4 hybrid plasmid).2 Here, we report a novel case of co-localization of blaOXA-162 carbapenemase and mcr-1 on a transferable IncHI2 plasmid in E. coli from a healthy broiler chicken in Europe.

AB - Carbapenems are critically important antimicrobials for the treatment of clinical infections caused by MDR Enterobacteriaceae, with colistin reserved for those cases in which even carbapenems are ineffective. Therefore, co-localization of carbapenem and colistin resistance genes on the same plasmid is worrisome and, to date, has been described only in China in an Escherichia coli from a diseased chicken (blaNDM-4 and mcr-1 on an IncHI2/ST3 plasmid)1 and in an E. coli from a diseased pet cat (blaNDM-5 and mcr-1 on an IncX3-X4 hybrid plasmid).2 Here, we report a novel case of co-localization of blaOXA-162 carbapenemase and mcr-1 on a transferable IncHI2 plasmid in E. coli from a healthy broiler chicken in Europe.

U2 - 10.1093/jac/dkab285

DO - 10.1093/jac/dkab285

M3 - Letter

C2 - 34392339

SN - 0305-7453

VL - 76

SP - 3063

EP - 3065

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 11

M1 - dkab285

ER -