Co-evolution of secondary metabolite gene clusters and their host

Inge Kjærbølling, Tammi Camilla Vesth, Jens Christian Frisvad, Jane Lind Nybo Rasmussen, Sebastian Theobald, Thomas Ostenfeld Larsen, Uffe Hasbro Mortensen, Mikael Rørdam Andersen

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    Abstract

    Secondary metabolite gene cluster evolution is mainly driven by two events: gene duplication and annexation and horizontal gene transfer. Here we use comparative genomics of Aspergillus species to investigate the evolution of secondary metabolite (SM) gene clusters across a wide spectrum of species. We investigate the dynamic evolutionary relationship between the cluster and the host by examining the genes within the cluster and the number of homologous genes found within the host and in closely related species.
    Original languageEnglish
    Publication date2016
    Number of pages1
    Publication statusPublished - 2016
    Event15th European Conference on Computational Biology - Churchillplein 10, 2517 JW, Den Haag, Netherlands
    Duration: 3 Sep 20167 Sep 2016
    Conference number: 15

    Conference

    Conference15th European Conference on Computational Biology
    Number15
    LocationChurchillplein 10, 2517 JW
    CountryNetherlands
    CityDen Haag
    Period03/09/201607/09/2016

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