Co-evolution of secondary metabolite gene clusters and their host

Inge Kjærbølling; Tammi Camilla Vesth; Jens Christian Frisvad; Jane Lind Nybo Rasmussen; Sebastian Theobald; Thomas Ostenfeld Larsen; Uffe Hasbro Mortensen; Mikael Rørdam Andersen

Co-evolution of secondary metabolite gene clusters and their host

Inge Kjærbølling, Tammi Camilla Vesth, Jens Christian Frisvad, Jane Lind Nybo Rasmussen, Sebastian Theobald, Thomas Ostenfeld Larsen, Uffe Hasbro Mortensen, Mikael Rørdam Andersen

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Abstract

Secondary metabolite gene cluster evolution is mainly driven by two events: gene duplication and annexation and horizontal gene transfer. Here we use comparative genomics of Aspergillus species to investigate the evolution of secondary metabolite (SM) gene clusters across a wide spectrum of species. We investigate the dynamic evolutionary relationship between the cluster and the host by examining the genes within the cluster and the number of homologous genes found within the host and in closely related species.

Original language	English
Publication date	2016
Number of pages	1
Publication status	Published - 2016
Event	15th European Conference on Computational Biology - Churchillplein 10, 2517 JW, Den Haag, Netherlands Duration: 3 Sept 2016 → 7 Sept 2016 Conference number: 15

Conference

Conference	15th European Conference on Computational Biology
Number	15
Location	Churchillplein 10, 2517 JW
Country/Territory	Netherlands
City	Den Haag
Period	03/09/2016 → 07/09/2016

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title = "Co-evolution of secondary metabolite gene clusters and their host",

abstract = "Secondary metabolite gene cluster evolution is mainly driven by two events: gene duplication and annexation and horizontal gene transfer. Here we use comparative genomics of Aspergillus species to investigate the evolution of secondary metabolite (SM) gene clusters across a wide spectrum of species. We investigate the dynamic evolutionary relationship between the cluster and the host by examining the genes within the cluster and the number of homologous genes found within the host and in closely related species. ",

author = "Inge Kj{\ae}rb{\o}lling and Vesth, {Tammi Camilla} and Frisvad, {Jens Christian} and Rasmussen, {Jane Lind Nybo} and Sebastian Theobald and Larsen, {Thomas Ostenfeld} and Mortensen, {Uffe Hasbro} and Andersen, {Mikael R{\o}rdam}",

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language = "English",

note = "15th European Conference on Computational Biology, ECCB 2016 ; Conference date: 03-09-2016 Through 07-09-2016",

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TY - ABST

T1 - Co-evolution of secondary metabolite gene clusters and their host

AU - Kjærbølling, Inge

AU - Vesth, Tammi Camilla

AU - Frisvad, Jens Christian

AU - Rasmussen, Jane Lind Nybo

AU - Theobald, Sebastian

AU - Larsen, Thomas Ostenfeld

AU - Mortensen, Uffe Hasbro

AU - Andersen, Mikael Rørdam

N1 - Conference code: 15

PY - 2016

Y1 - 2016

N2 - Secondary metabolite gene cluster evolution is mainly driven by two events: gene duplication and annexation and horizontal gene transfer. Here we use comparative genomics of Aspergillus species to investigate the evolution of secondary metabolite (SM) gene clusters across a wide spectrum of species. We investigate the dynamic evolutionary relationship between the cluster and the host by examining the genes within the cluster and the number of homologous genes found within the host and in closely related species.

AB - Secondary metabolite gene cluster evolution is mainly driven by two events: gene duplication and annexation and horizontal gene transfer. Here we use comparative genomics of Aspergillus species to investigate the evolution of secondary metabolite (SM) gene clusters across a wide spectrum of species. We investigate the dynamic evolutionary relationship between the cluster and the host by examining the genes within the cluster and the number of homologous genes found within the host and in closely related species.

M3 - Conference abstract for conference

T2 - 15th European Conference on Computational Biology

Y2 - 3 September 2016 through 7 September 2016

ER -

Co-evolution of secondary metabolite gene clusters and their host

Abstract

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