Co-assembly of chitosan and phospholipids into hybrid hydrogels

Ana Carina Loureiro Mendes; Elhamalsadat Shekarforoush; Christoph Engwer; Sophie Beeren; Francisco M. Goycoolea; Ioannis S. Chronakis

doi:10.1515/pac-2016-0708

Co-assembly of chitosan and phospholipids into hybrid hydrogels

Ana Carina Loureiro Mendes, Elhamalsadat Shekarforoush, Christoph Engwer, Sophie Beeren, Francisco M. Goycoolea, Ioannis S. Chronakis

Research output: Contribution to journal › Conference article › Research › peer-review

Abstract

Novel hybrid hydrogels were formed by adding chitosan (Ch) to phospholipids (P) self-assembled particles in lactic acid. The effect of the phospholipid concentration on the hydrogel properties was investigated and was observed to affect the rate of hydrogel formation and viscoelastic properties. A lower concentration of phospholipids (0.5% wt/v) in the mixture, facilitates faster network formation as observed by Dynamic Light Scattering, with lower elastic modulus than the hydrogels formed with higher phospholipid content. The nano-porous structure of Ch/P hydrogels, with a diameter of 260±20 nm, as observed by cryo-scanning electron microscopy, facilitated the penetration of water and swelling. Cell studies revealed suitable biocompatibility of the Ch/P hydrogels that can be used within life sciences applications.

Original language	English
Journal	Pure and Applied Chemistry
Volume	88
Issue number	9
Pages (from-to)	905-916
ISSN	0033-4545
DOIs	https://doi.org/10.1515/pac-2016-0708
Publication status	Published - 2016
Event	12th Conference of the European Chitin Society - Münster, Germany Duration: 30 Aug 2016 → 2 Sep 2016

Conference

Conference	12th Conference of the European Chitin Society
Country	Germany
City	Münster
Period	30/08/2016 → 02/09/2016

Keywords

biomaterials
carbohydrates
chitosan
colloids
EUCHIS-12
hydrogel
ICCC-13
phospholipids
self-assembly

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@inproceedings{4244102e79e04ca881f22b73e08751a6,

title = "Co-assembly of chitosan and phospholipids into hybrid hydrogels",

abstract = "Novel hybrid hydrogels were formed by adding chitosan (Ch) to phospholipids (P) self-assembled particles in lactic acid. The effect of the phospholipid concentration on the hydrogel properties was investigated and was observed to affect the rate of hydrogel formation and viscoelastic properties. A lower concentration of phospholipids (0.5% wt/v) in the mixture, facilitates faster network formation as observed by Dynamic Light Scattering, with lower elastic modulus than the hydrogels formed with higher phospholipid content. The nano-porous structure of Ch/P hydrogels, with a diameter of 260±20 nm, as observed by cryo-scanning electron microscopy, facilitated the penetration of water and swelling. Cell studies revealed suitable biocompatibility of the Ch/P hydrogels that can be used within life sciences applications.",

keywords = "biomaterials, carbohydrates, chitosan, colloids, EUCHIS-12, hydrogel, ICCC-13, phospholipids, self-assembly",

author = "Mendes, {Ana Carina Loureiro} and Elhamalsadat Shekarforoush and Christoph Engwer and Sophie Beeren and Goycoolea, {Francisco M.} and Chronakis, {Ioannis S.}",

year = "2016",

doi = "10.1515/pac-2016-0708",

language = "English",

volume = "88",

pages = "905--916",

journal = "Pure and Applied Chemistry",

issn = "0033-4545",

publisher = "Walterde Gruyter GmbH",

number = "9",

note = "12th Conference of the European Chitin Society ; Conference date: 30-08-2016 Through 02-09-2016",

}

TY - GEN

T1 - Co-assembly of chitosan and phospholipids into hybrid hydrogels

AU - Mendes, Ana Carina Loureiro

AU - Shekarforoush, Elhamalsadat

AU - Engwer, Christoph

AU - Beeren, Sophie

AU - Goycoolea, Francisco M.

AU - Chronakis, Ioannis S.

PY - 2016

Y1 - 2016

N2 - Novel hybrid hydrogels were formed by adding chitosan (Ch) to phospholipids (P) self-assembled particles in lactic acid. The effect of the phospholipid concentration on the hydrogel properties was investigated and was observed to affect the rate of hydrogel formation and viscoelastic properties. A lower concentration of phospholipids (0.5% wt/v) in the mixture, facilitates faster network formation as observed by Dynamic Light Scattering, with lower elastic modulus than the hydrogels formed with higher phospholipid content. The nano-porous structure of Ch/P hydrogels, with a diameter of 260±20 nm, as observed by cryo-scanning electron microscopy, facilitated the penetration of water and swelling. Cell studies revealed suitable biocompatibility of the Ch/P hydrogels that can be used within life sciences applications.

AB - Novel hybrid hydrogels were formed by adding chitosan (Ch) to phospholipids (P) self-assembled particles in lactic acid. The effect of the phospholipid concentration on the hydrogel properties was investigated and was observed to affect the rate of hydrogel formation and viscoelastic properties. A lower concentration of phospholipids (0.5% wt/v) in the mixture, facilitates faster network formation as observed by Dynamic Light Scattering, with lower elastic modulus than the hydrogels formed with higher phospholipid content. The nano-porous structure of Ch/P hydrogels, with a diameter of 260±20 nm, as observed by cryo-scanning electron microscopy, facilitated the penetration of water and swelling. Cell studies revealed suitable biocompatibility of the Ch/P hydrogels that can be used within life sciences applications.

KW - biomaterials

KW - carbohydrates

KW - chitosan

KW - colloids

KW - EUCHIS-12

KW - hydrogel

KW - ICCC-13

KW - phospholipids

KW - self-assembly

U2 - 10.1515/pac-2016-0708

DO - 10.1515/pac-2016-0708

M3 - Conference article

VL - 88

SP - 905

EP - 916

JO - Pure and Applied Chemistry

JF - Pure and Applied Chemistry

SN - 0033-4545

IS - 9

T2 - 12th Conference of the European Chitin Society

Y2 - 30 August 2016 through 2 September 2016

ER -