Abstract
Novel hybrid hydrogels were formed by adding chitosan (Ch) to phospholipids (P) self-assembled particles in lactic acid. The effect of the phospholipid concentration on the hydrogel properties was investigated and was observed to affect the rate of hydrogel formation and viscoelastic properties. A lower concentration of phospholipids (0.5% wt/v) in the mixture, facilitates faster network formation as observed by Dynamic Light Scattering, with lower elastic modulus than the hydrogels formed with higher phospholipid content. The nano-porous structure of Ch/P hydrogels, with a diameter of 260±20 nm, as observed by cryo-scanning electron microscopy, facilitated the penetration of water and swelling. Cell studies revealed suitable biocompatibility of the Ch/P hydrogels that can be used within life sciences applications.
Original language | English |
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Journal | Pure and Applied Chemistry |
Volume | 88 |
Issue number | 9 |
Pages (from-to) | 905-916 |
ISSN | 0033-4545 |
DOIs | |
Publication status | Published - 2016 |
Event | 12th International Conference of the European Chitin Society - Münster, Germany Duration: 30 Aug 2015 → 2 Sept 2015 Conference number: 12 https://euchis.org/wp-content/uploads/2014/12/flyereuchis2015.pdf |
Conference
Conference | 12th International Conference of the European Chitin Society |
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Number | 12 |
Country/Territory | Germany |
City | Münster |
Period | 30/08/2015 → 02/09/2015 |
Internet address |
Keywords
- biomaterials
- carbohydrates
- chitosan
- colloids
- EUCHIS-12
- hydrogel
- ICCC-13
- phospholipids
- self-assembly