Co-assembly of chitosan and phospholipids into hybrid hydrogels

Ana Carina Loureiro Mendes, Elhamalsadat Shekarforoush, Christoph Engwer, Sophie Beeren, Francisco M. Goycoolea, Ioannis S. Chronakis

Research output: Contribution to journalConference articleResearchpeer-review

Abstract

Novel hybrid hydrogels were formed by adding chitosan (Ch) to phospholipids (P) self-assembled particles in lactic acid. The effect of the phospholipid concentration on the hydrogel properties was investigated and was observed to affect the rate of hydrogel formation and viscoelastic properties. A lower concentration of phospholipids (0.5% wt/v) in the mixture, facilitates faster network formation as observed by Dynamic Light Scattering, with lower elastic modulus than the hydrogels formed with higher phospholipid content. The nano-porous structure of Ch/P hydrogels, with a diameter of 260±20 nm, as observed by cryo-scanning electron microscopy, facilitated the penetration of water and swelling. Cell studies revealed suitable biocompatibility of the Ch/P hydrogels that can be used within life sciences applications.
Original languageEnglish
JournalPure and Applied Chemistry
Volume88
Issue number9
Pages (from-to)905-916
ISSN0033-4545
DOIs
Publication statusPublished - 2016
Event12th Conference of the European Chitin Society - Münster, Germany
Duration: 30 Aug 20162 Sep 2016

Conference

Conference12th Conference of the European Chitin Society
CountryGermany
CityMünster
Period30/08/201602/09/2016

Keywords

  • biomaterials
  • carbohydrates
  • chitosan
  • colloids
  • EUCHIS-12
  • hydrogel
  • ICCC-13
  • phospholipids
  • self-assembly

Fingerprint Dive into the research topics of 'Co-assembly of chitosan and phospholipids into hybrid hydrogels'. Together they form a unique fingerprint.

Cite this