Novel hybrid hydrogels were formed by adding chitosan (Ch) to phospholipids (P) self-assembled particles in lactic acid. The effect of the phospholipid concentration on the hydrogel properties was investigated and was observed to affect the rate of hydrogel formation and viscoelastic properties. A lower concentration of phospholipids (0.5% wt/v) in the mixture, facilitates faster network formation as observed by Dynamic Light Scattering, with lower elastic modulus than the hydrogels formed with higher phospholipid content. The nano-porous structure of Ch/P hydrogels, with a diameter of 260±20 nm, as observed by cryo-scanning electron microscopy, facilitated the penetration of water and swelling. Cell studies revealed suitable biocompatibility of the Ch/P hydrogels that can be used within life sciences applications.
|Journal||Pure and Applied Chemistry|
|Publication status||Published - 2016|
|Event||12th Conference of the European Chitin Society - Münster, Germany|
Duration: 30 Aug 2016 → 2 Sep 2016
|Conference||12th Conference of the European Chitin Society|
|Period||30/08/2016 → 02/09/2016|