ClusterSignificance: A bioconductor package facilitating statistical analysis of class cluster separations in dimensionality reduced data

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Summary Multi-dimensional data generated via high-throughput experiments is increasingly used in conjunction with dimensionality reduction methods to ascertain if resulting separations of the data correspond with known classes. This is particularly useful to determine if a subset of the variables, e.g. genes in a specific pathway, alone can separate samples into these established classes. Despite this, the evaluation of class separations is often subjective and performed via visualization. Here we present the ClusterSignificance package; a set of tools designed to assess the statistical significance of class separations downstream of dimensionality reduction algorithms. In addition, we demonstrate the design and utility of the ClusterSignificance package and utilize it to determine the importance of long non-coding RNA expression in the identity of multiple hematological malignancies.

Original languageEnglish
JournalBioinformatics
Volume33
Issue number19
Pages (from-to)3126-3128
ISSN1367-4803
DOIs
Publication statusPublished - 2017
CitationsWeb of Science® Times Cited: No match on DOI

ID: 138511434