Clustering of cardiovascular diseases in family members of young sudden cardiac death victims: A Danish nationwide cohort study

M. F. Ranthe, B. G. Winkel, Elisabeth Wreford Andersen, B. Risgaard, J. Wohlfahrt, H. Bundgaard, M. Melbye, J. Tfelt-Hansen, H. A. Boyd

Research output: Contribution to journalConference abstract in journalResearchpeer-review


Purpose: Descriptive studies have indicated clustering of cardiovascular diseases (CVDs) in families with victims of sudden cardiac death (SCD). These studies included highly selected cases often from tertiary referral centers and had no control groups. This population-based cohort study, aimed to prospectively describe the occurrence of CVDs in young relatives of young SCD victims, compared to the background population.
Methods: In Denmark, 2000-2006, all cases of SCD aged 1-35 years were identified. We compared the incidence of CVD in young persons related to those victims of SCD, with the background population in a follow-up study using Standardized Incidence Ratios (SIRs) to estimate relative risks.
Results: For 463 victims of SCD we identified a nationwide cohort of 1,591 first- and second-degree relatives aged <35 years, and followed for more than 7,000 person-years in 2000-2008. The observed number of CVDs were 32 and the expected number based on national rates was 8.4, SIR w. 95% confidence interval (CI) 3.79 (2.68-5.36). For cardiomyopathy and ventricular arrhythmia corresponding SIRs were 15.78 (5.12-36.83) and 11.19 (4.37-25.93), respectively. Sex of SCD victim and/or cohort member had no significant effect on SIRs. The table shows SIR for CVD and subgroups, for those with an SCD in a young first-degree relative.
Original languageEnglish
JournalEuropean Heart Journal
Issue number1
Pages (from-to)175-175
Publication statusPublished - 2012
Externally publishedYes
EventCongress of the European-Society-of-Cardiology (ESC) - Munchen, Germany
Duration: 25 Aug 201229 Aug 2012


ConferenceCongress of the European-Society-of-Cardiology (ESC)


  • Denmark Europe Palearctic region
  • Danish nationwide cohort study
  • cardiomyopathy Cardiomyopathy, Congestive (MeSH) heart disease
  • cardiovascular disease Cardiovascular Diseases (MeSH) heart disease, vascular disease epidemiology
  • sudden cardiac death Death, Sudden, Cardiac (MeSH) heart disease mortality
  • ventricular arrhythmia Arrhythmia (MeSH) heart disease
  • Primates Mammalia Vertebrata Chordata Animalia (Animals, Chordates, Humans, Mammals, Primates, Vertebrates) - Hominidae [86215] human common child, preadolescent child, infant, adult, adolescent
  • 00520, General biology - Symposia, transactions and proceedings
  • 14506, Cardiovascular system - Heart pathology
  • 14508, Cardiovascular system - Blood vessel pathology
  • 25000, Pediatrics
  • 37054, Public health: epidemiology - Organic diseases and neoplasms
  • 37056, Public health: epidemiology - Miscellaneous
  • Human Medicine, Medical Sciences
  • Population Studies
  • Cardiovascular Medicine
  • Epidemiology


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