Clonal origin of aminoglycoside-resistant Citrobacter freundii isolates in a Danish county

N. Norskov-Lauritsen, Dorthe Sandvang, J. Hedegaard, V. Fussing, K.K. Mortensen, H.U. Sperling-Petersen, H.C. Schonheyder

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    During 1997, attention was drawn to an increased frequency of aminoglycoside-resistant Citrobacter freundii in a Danish county, when a total of 24 resistant C. freundii isolates was detected. In this study, 15 such isolates were typed by pulsed-field gel electrophoresis, riboprinting and partial sequencing of the gene encoding translation initiation factor 2. Fourteen of the 15 isolates were identical, as evaluated by their antibiograms and by all these typing methods, This epidemic strain harboured the aminoglycoside resistance genes aac(3)-II and ant(3")-I, with the latter located in tandem with a dihydrofolate reductase gene in a class I integron. The source of the strain remains unresolved. Representative isolates were obtained from various specimens from hospitals and general practice throughout the county, with no evidence of patient-to-patient transmission.
    Original languageEnglish
    JournalJournal of Medical Microbiology
    Volume50
    Issue number7
    Pages (from-to)636-641
    ISSN0022-2615
    Publication statusPublished - 2001

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