Clinical Presentation and Immune Status of Children Infected by Multi-Drug-Resistant Salmonella Strains

Z. U. Gevorgyan, L. A. Ktsoyan, N. N. Sarkisyan, A. M. Sedrakyan, K. A. Arakelova, Zh. A. Ktsoyan, A. V. Asoyan, K. A. Kazaryan, K. G. Karageuzyan, Rustam Aminov

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Abstract

A total of 145 infected children of various age groups hospitalized at the Yerevan Hospital of Infectious Diseases were treated by salmonellosis within a three-year period. Among the 138 Salmonella strains, isolated from these patients, the majority (56%) were typed as S. typhimurium. Antibiotic resistance profiling demonstrated no pan susceptible Salmonella, the majority of strains were resistant to 5 and more antibiotics and antimicrobial compounds. Clinically, the severity of disease correlated with Salmonella serotype, 50% of acute diseases were associated with S. typhimurium and related serotypes. In the age group of 1 to 12 months, the level of main immunoglobulin classes (IgG, IgA, and IgM) exceeded the age norm by more than 40% in 60% of patients. In 95% of patients of this age group, the T-lymphocyte population was decreased by 38%. Immunoglobulin therapy of these patients failed to normalize the level of the three main immunoglobulin classes.
Original languageEnglish
JournalElectronic Journal of Natural Sciences
Volume2
Issue number1
Pages (from-to)46-50
Number of pages1
ISSN1728-791X
Publication statusPublished - 2004
Externally publishedYes

Keywords

  • INFECTION

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