"Clickable" LNA/DNA probes for fluorescence sensing of nucleic acids and autoimmune antibodies

Anna S. Jorgensen; Pankaj Gupta; Jesper Wengel; Kira Astakhova

doi:10.1039/c3cc45507f

"Clickable" LNA/DNA probes for fluorescence sensing of nucleic acids and autoimmune antibodies

Anna S. Jorgensen, Pankaj Gupta, Jesper Wengel, Kira Astakhova

University of Southern Denmark

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Abstract

Herein we describe fluorescent oligonucleotides prepared by click chemistry between novel alkyne-modified locked nucleic acid (LNA) strands and a series of fluorescent azides for homogeneous (all-in-solution) detection of nucleic acids and autoimmune antibodies.

Original language	English
Journal	Chemical Communications
Volume	49
Issue number	91
Pages (from-to)	10751-10753
Number of pages	3
ISSN	1359-7345
DOIs	https://doi.org/10.1039/c3cc45507f
Publication status	Published - 2013
Externally published	Yes

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Open Access Article. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

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@article{9d9fa769c0794a92a896af708e76c570,

title = "{"}Clickable{"} LNA/DNA probes for fluorescence sensing of nucleic acids and autoimmune antibodies",

abstract = "Herein we describe fluorescent oligonucleotides prepared by click chemistry between novel alkyne-modified locked nucleic acid (LNA) strands and a series of fluorescent azides for homogeneous (all-in-solution) detection of nucleic acids and autoimmune antibodies.",

author = "Jorgensen, {Anna S.} and Pankaj Gupta and Jesper Wengel and Kira Astakhova",

note = "Open Access Article. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.",

year = "2013",

doi = "10.1039/c3cc45507f",

language = "English",

volume = "49",

pages = "10751--10753",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "91",

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T1 - "Clickable" LNA/DNA probes for fluorescence sensing of nucleic acids and autoimmune antibodies

AU - Jorgensen, Anna S.

AU - Gupta, Pankaj

AU - Wengel, Jesper

AU - Astakhova, Kira

N1 - Open Access Article. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

PY - 2013

Y1 - 2013

N2 - Herein we describe fluorescent oligonucleotides prepared by click chemistry between novel alkyne-modified locked nucleic acid (LNA) strands and a series of fluorescent azides for homogeneous (all-in-solution) detection of nucleic acids and autoimmune antibodies.

AB - Herein we describe fluorescent oligonucleotides prepared by click chemistry between novel alkyne-modified locked nucleic acid (LNA) strands and a series of fluorescent azides for homogeneous (all-in-solution) detection of nucleic acids and autoimmune antibodies.

U2 - 10.1039/c3cc45507f

DO - 10.1039/c3cc45507f

M3 - Journal article

SN - 1359-7345

VL - 49

SP - 10751

EP - 10753

JO - Chemical Communications

JF - Chemical Communications

IS - 91

ER -

"Clickable" LNA/DNA probes for fluorescence sensing of nucleic acids and autoimmune antibodies

Abstract

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